中国中药杂志

2004, (10)

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2种仙人掌多糖对S180小鼠红细胞膜蛋白和膜脂流动性影响的研究
Study on the effects of two kinds of cactus polysaccharide on erythrocyte membrane protein and fluidity of the lipid in S180 mice

季宇彬,汲晨锋,邹翔,高世勇
JI Yu-bin, JI Chen-feng, ZOU Xiang, GAO Shi-yong (Postdoctal Research of the Institute of Materia Medica, Harbin Uni versity of Commerce, Harbin 150076, China) [

摘要(Abstract):

目的 :研究 2种仙人掌多糖对S180小鼠红细胞膜带 3蛋白含量、交联蛋白含量、膜脂流动性的影响。方法 :应用SDS 聚丙烯酰胺电泳实验分析膜蛋白含量 ,按Skinitzky法测定膜脂流动性。结果 :2种仙人掌多糖可增加荷瘤小鼠红细胞膜带 3蛋白的含量 ,降低膜交联蛋白含量 ,提高膜脂流动性。其中 ,药用仙人掌多糖的中剂量组效果显著 (P <0 0 1) ,食用仙人掌多糖的高剂量组效果显著 (P <0 0 1)。结论 :两种仙人掌多糖通过改善荷瘤小鼠红细胞膜功能 ,增强了小鼠的免疫功能 ,可能是仙人掌多糖抗肿瘤作用的机制之一。
Objective: To study the effects of two ki nd s of cactus polysaccharide on Band 3 protein, cross-linking protein and lipid fluidity of erythrocyte membrane in S180 mice. Method: The membrane protein content was analysed by SDS-PAGE. Lipid fluid ity was measured by Skinitzky method. Result: The two ki nds of cactus polysaccharide increased the content of Band 3 protein and decreased the conten t of cross-linking protein, raised the lipid fluidity. While the effect of me dian dose group of medical cactus polysaccharide is very remarkable(P<0.0 1), the effect of high dose group of edible cactus polysaccharide is very rema rkable(P<0.01). Conclusion: By improving the ery throcyte membrane function of tumor-mice, they enhanced the immune function, which may be one of anti-tumor mechanisms. [

关键词(KeyWords): 仙人掌;多糖;带3蛋白;交联蛋白;膜脂流动性
cactus; polysaccharide; band 3 protein; cross-linking protein; lipid fluidity

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基金项目(Foundation): 黑龙江省青年基金资助项目资助 (QC0 2C46)

作者(Author): 季宇彬,汲晨锋,邹翔,高世勇
JI Yu-bin, JI Chen-feng, ZOU Xiang, GAO Shi-yong (Postdoctal Research of the Institute of Materia Medica, Harbin Uni versity of Commerce, Harbin 150076, China) [

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