中国中药杂志

2010, v.35(06) 786-789

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良性前列腺增生症细胞因子水平与中药干预的研究
Influence of intervene of traditional Chinese medicine on cytokine level in benign prostatic hyperplasia

汪浩;舒跃民;郑海文;武东;黄斌伦;高素华;
WANG Hao1,SHU Yuemin 2,ZHENG Haiwen1,WU Dong3,HUANG Binlun1,GAO Suhua1 (1.School of Medicine,Jinhua Colloge of Profession and Tecnology,Jinhua 321017,China;2.Jinhua People's Hospital,Jinhua 321000,China;3.Hospital of Twelfth Bureau of China's Water Conservancy and Hydroelectric Power,Jinhua 321027,China)

摘要(Abstract):

目的:研究良性前列腺增生症细胞因子水平与中药干预的影响。方法:采用随机病例对照设治疗组(A组),对照组(B组)及健康组(C组)。A组用前列宁汤,每日1剂,分2次口服。B组用前列康3片/次,每日3次口服,2组疗程均8周。结果:治疗前AB组TNF-α,IL-17/IL-10,IL-4与C组比明显失调(P<0.01)。治疗后A组TNF-α,IL-17明显降低,IL-10,IL-4明显提高,与治疗前比有显著性差异(P<0.01)。与B组比有显著性差异(P<0.01)。但仍然达不到C组水平。结论:前列宁汤能有效调节前炎症细胞因子与抗炎症细胞因子的水平,为临床诊断与治疗BPH提供科学实验依据。
Objective: To make a study of the influence of the intervene of traditional Chinese medicine on cytokine level in benign prostatic hyperplasia.Method: The patients were divided into treatment group(group A),control group(group B) and healthy group(group C) with the randomly compared researching method.Group A were given Qianliening Tang(QLNT),daily potion,two times a day.Group B were given Qianliekang,three times a day,three pills each time.The course of both treatment lasted for 8 weeks.Result: Before treatment,TNF-α,IL-17/IL-10,IL-4 in group A and B are obviously out of order compared with group C(P<0.01).After the treatment,TNF-α,IL-17 in group A decreased dramatically and IL-10,IL-4 increased,which shows great differences compared with those before treatment and with group B(P<0.01),but still can't reach to group C level.Conclusion: Qian liening Tang can efficiently regulate the level of suppressive inflammatory cytokines and proinflammatory cytokines.It provides scientific experimental basis for clinical diagnosis and treatment of the disease.

关键词(KeyWords): 良性前列腺增生症;细胞因子;中药;前列宁汤;干预
benign prostatic hyperplasia;cytokines;traditional Chinese medicine;Qianliening Tang;intervene

Abstract:

Keywords:

基金项目(Foundation): 浙江省金华市科技局项目(2009-3-255)

作者(Authors): 汪浩;舒跃民;郑海文;武东;黄斌伦;高素华;
WANG Hao1,SHU Yuemin 2,ZHENG Haiwen1,WU Dong3,HUANG Binlun1,GAO Suhua1 (1.School of Medicine,Jinhua Colloge of Profession and Tecnology,Jinhua 321017,China;2.Jinhua People's Hospital,Jinhua 321000,China;3.Hospital of Twelfth Bureau of China's Water Conservancy and Hydroelectric Power,Jinhua 321027,China)

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