中国中药杂志

2019, v.44(23) 5102-5108

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铁皮石斛干预代谢综合征的作用分子机制研究进展
Research progress on molecular mechanism of Dendrobium officinale and its active components to metabolic syndrome

李毓扬;吕承豪;吴广;郑志兵;罗毅波;覃思;
LI Yu-yang;LYU Cheng-hao;WU Guang;ZHENG Zhi-bing;LUO Yi-bo;QIN Si;College of Food Science and Technology,Hunan Agricultural University;State Key Laboratory of Systems and Evolutionary Botany,Institute of Botany,Chinese Academy of Sciences;

摘要(Abstract):

代谢综合征是一类以高血糖、血脂异常和高血压等症状为标志的临床综合征,其发生率日益增加且呈年轻化,更重要的是,长时间维持这种状况会显著增加糖尿病、心血管疾病和癌症等慢性疾病的发病率。然而,代谢综合征的形成机制非常复杂,尚没有被充分研究和揭示。铁皮石斛是一种具有多种生理功能的传统药食两用物质,近年来因被报道有改善血脂、降低血压、调节血糖等功效而引起了广泛的关注。但目前尚无系统阐述铁皮石斛干预代谢综合征的生理功效及其分子机制研究现状的综述。该文首先综述了铁皮石斛所含有主要功能成分的生物活性及近年来其功能产品的研发和应用现状,然后简述了铁皮石斛及其功能成分在体内的消化、吸收及安全毒理性等特性,最后重点归纳和总结了铁皮石斛干预动物及人体代谢综合征的作用效果并在细胞水平分析了其可能存在的分子机制。该文为铁皮石斛及其功能成分的进一步研究与开发应用,特别是其可能的临床应用提供了有力的理论指导和可靠的分子依据。
Metabolic syndrome,a kind of clinical syndrome marked by the presence of symptoms such as hyperglycemia,dyslipidemia and hypertension,has an increasing incidence and comes to be present in younger people. More importantly,prolonged maintenance of this condition can significantly increase the incidence of chronic diseases such as diabetes,cardiovascular disease and cancer.However,the formation mechanism of metabolic syndrome is very complex and has not been fully studied and revealed. Dendrobium officinale is a traditional medicine and food substance with multiple physiological functions. In recent years,D. officinale has attracted much attention from the scholars both at home and abroad due to its functions such as improving blood lipid,lowering blood pressure and regulating blood sugar. However,there is no systematic review on the current studies about D. officinale in intervening metabolic syndrome and its underlying molecular mechanism. In this paper,the biological activity of the main active components,and the research or application status of D. officinale extract in the recent years were reviewed. Then,we analyzed the digestion,absorption and the safety and toxicity of D. officinale and its active components in the body. Finally,we summarized the effects of D. officinale and its active components on metabolic syndrome in animals and human bodies,and discussed its possible molecular mechanisms at the cellular level. This paper provides solid theoretical guidance and reliable molecular basis for further research and advanced development of D. officinale and its active components,especially for its oncoming clinical application.

关键词(KeyWords): 铁皮石斛;代谢综合征;干预;分子机制
Dendrobium officinale;metabolic syndrome;intervention;molecular mechanism

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基金项目(Foundation): 国家自然科学基金项目(31101268);; 湖南省自然科学基金项目(2019JJ40132);; 湖南省科技攻关计划项目(2017NK2093)

作者(Author): 李毓扬;吕承豪;吴广;郑志兵;罗毅波;覃思;
LI Yu-yang;LYU Cheng-hao;WU Guang;ZHENG Zhi-bing;LUO Yi-bo;QIN Si;College of Food Science and Technology,Hunan Agricultural University;State Key Laboratory of Systems and Evolutionary Botany,Institute of Botany,Chinese Academy of Sciences;

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