中国中药杂志

2015, v.40(12) 2349-2351

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植物内生真菌Periconia sp.F-31中的一个新内酯类化合物
A new lactone derivative from plant endophytic fungus Periconia sp. F-31

张德武;刘继梅;陈日道;张敏;余利岩;吴军;戴均贵;
ZHANG De-wu;LIU Ji-mei;CHEN Ri-dao;ZHANG Min;YU Li-yan;WU Jun;DAI Jun-gui;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College;College of Pharmacy,Ji'nan University;

摘要(Abstract):

对一株番荔枝内生真菌Periconia sp.F-31中的次生代谢产物进行研究。通过硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC等方法分离纯化得到了2个化合物,根据波谱学方法分别鉴定为5-(1-羟己基)-6-甲基-2H-吡喃-2-酮(1)、2-(3-羟基-4-甲基苯)-丙酸(2)。化合物1为新化合物,化合物2为新的天然产物,首次对化合物2的NMR数据进行了报道。
To investigate the secondary metabolites of endophytic fungi Pericinia sp. F-31. Column chromatography on silica gel,Sephadex LH-20 and semi-preparative HPLC were used to separate and purify the compounds. Two compounds were isolated from the fermentation broth of Periconia sp. Their structures were identified as 5-(1-hydroxyhexyl)-6-methyl-2H-pyran-2-one(1) and 2-(3-hydroxy-4-methylphenyl)-propanoic acid(2). Compound 1 was a new lactone compound,compound 2 was new natural product,and the NMR data of compound 2 was reported for the first time.

关键词(KeyWords): 内生真菌;Periconia;内酯;化学成分
endophytic fungus;Periconia;lactone;chemical constituents

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基金项目(Foundation): 广东省重大科技专项(2011A080403020)

作者(Author): 张德武;刘继梅;陈日道;张敏;余利岩;吴军;戴均贵;
ZHANG De-wu;LIU Ji-mei;CHEN Ri-dao;ZHANG Min;YU Li-yan;WU Jun;DAI Jun-gui;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College;College of Pharmacy,Ji'nan University;

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