中国中药杂志

2006, (24) 2042-2045

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均匀设计法优化超临界CO_2流体萃取丹参中丹参酮工艺的研究
Study on Uniform-design for optimizing supercritical-CO_2 fluid extraction technique of tanshinones in Radix Salviae

何雁;刘勇;李毅;罗晓健;
LUO Xiao-jian~1 LIU Yong~2 LI Yi~2 HE Yan~2 (1.National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China;2.Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)

摘要(Abstract):

目的:探讨超临界CO_2流体萃取法萃取丹参中丹参酮的最佳工艺条件。方法:用高效液相色谱法测定丹参酮含量,以萃取物中3种丹参酮总含量为指标,采用均匀设计法对影响萃取结果的主要因素进行考察。结果:夹带剂用量对萃取结果影响最为显著。最佳萃取工艺参数为:萃取压力30 MPa;萃取温度40℃;分离釜Ⅰ压力6 MPa;分离釜Ⅰ温度50℃;夹带剂用量10%。结论:超临界CO_2流体萃取法萃取丹参中丹参酮是一种切实可行的方法。所得萃取产物中丹参酮含量高,萃取时间短,操作简便。
Objective:To explore the optimal supercritieal-CO_2 fluid extraction technique of extracting tanshinones in Radix salviae.Method:The contents of tanshinones were determined by HPLC.Choosing the overall contents of 3 tanshinones as inspecting marker and uniform-design as method,the experimentation was carried out to study the main factors that influence the result of extrac- tion.Result:Among all the 5 inspected factors,the amount of entrainer was most notable.The optimal technique of extraction was :ex- traction pressure at 30 MPa;extraction temperature at 40℃;separation pressure of separating kettleⅠat 6 MPa;separation tempera- ture of separating kettle I at 50℃;the amount of entrainer at 10%.Conclusion:Adopting supercritieal-CO_2 fluid extraction method to extract the tanshinones in Radix salviae was feasible.The contents of tanshinones in the extract were high and the manipulation was simple、convenient and time saving.

关键词(KeyWords): 超临界CO_2流体萃取;均匀设计法;高效液相色谱法;隐丹参酮;丹参酮Ⅰ;丹参酮Ⅱ_A
Supercritical-CO_2 fluid extraction;uniform-design;HPLC;cryptotanshinone;tanshinoneⅠ;tanshinoneⅡ_A

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作者(Author): 何雁;刘勇;李毅;罗晓健;
LUO Xiao-jian~1 LIU Yong~2 LI Yi~2 HE Yan~2 (1.National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine,Nanchang 330006,China;2.Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China)

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