中国中药杂志

2020, v.45(12) 2784-2791

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交泰丸的化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析
Review of chemical constituents, pharmacological effects and clinical applications of Jiaotai Pills and predictive analysis of its quality marker(Q-marker)

孙雨;杨钰涵;王珺;蒋海强;崔宁;苏本正;于宗渊;
SUN Yu;YANG Yu-han;WANG Jun;JIANG Hai-qiang;CUI Ning;SU Ben-zheng;YU Zong-yuan;College of Pharmacy, Shandong University of Traditional Chinese Medicine;Shandong Institute of Traditional Chinese Medicine;

摘要(Abstract):

交泰丸是治疗心肾不交的传统经方,具有交通心肾、镇静催眠、抗焦虑抑郁、改善胰岛素抵抗等作用,现代临床常用来治疗失眠、焦虑抑郁、糖尿病等。该文对交泰丸的化学成分、药理作用及临床应用的研究进展进行综述,基于中药质量标志物(Q-marker)"五原则"对交泰丸的Q-marker进行预测分析,提示小檗碱、表小檗碱、盐酸黄连碱、盐酸巴马汀、盐酸小檗碱、盐酸小檗红碱、阿魏酸、肉桂酸、桂皮醛、原花青素B2可作为交泰丸的Q-marker,后续可选择这些Q-marker成分作为指标,为交泰丸的质量控制研究提供参考。
Jiaotai Pills is a traditional medical prescription to treat the incompatibility of heart and kidney. It has the distinctive functions of heart and kidney communication, sedation and hypnosis, anti-anxiety and depression, as well as the improvement of insulin resistance. However, this pill is broadly used to cure insomnia, anxiety, depression, and diabetes in the contemporary clinical trials. Based on the article, it illustrates the research progress of the chemical ingredients, pharmacological actions, and clinical applications of Jiaotai Pills. With respect to the "five principles" of Q-marker in Chinese medicine, the Q-marker of Jiaotai Pills is comprehensively predicted and analyzed, noting that berberine, epiberberine, coptisine chloride, palmatine chloride, berberine chloride, berberrubine chloride, ferulic acid, cinnamic acid, cinnamaldehyde, proanthocyanidin B2 can be treated as the Q-marker of Jiaotai Pills. In addition, these components of Q-marker have been selected as indicators to provide a significant reference for the quality control and surveillance research of Jiaotai Pills.

关键词(KeyWords): 交泰丸;质量标志物;化学成分;药理作用;临床应用;质量控制
Jiaotai Pills;quality marker(Q-marker);chemical components;pharmacological effects;clinical applications;quality control

Abstract:

Keywords:

基金项目(Foundation): 山东省重大科技创新工程项目(2018CXGC1308)

作者(Author): 孙雨;杨钰涵;王珺;蒋海强;崔宁;苏本正;于宗渊;
SUN Yu;YANG Yu-han;WANG Jun;JIANG Hai-qiang;CUI Ning;SU Ben-zheng;YU Zong-yuan;College of Pharmacy, Shandong University of Traditional Chinese Medicine;Shandong Institute of Traditional Chinese Medicine;

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