中国中药杂志

2004, (01)

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脑脉通对老龄大鼠脑缺血/再灌注损伤脑保护作用的研究
Neuro-protective effect of naomaitong to brain damage after focal cerebral isc hemia reperfusion (I/R) in the aged rats

任小巧,李建生,封银曼,卢跃卿
REN Xiao-qiao, LI Jian-sheng, FENG Yin-man, LU Yue-qing (Henan College of Traditional Chinese Medincine, Zhengzhou 450008, Chi na)

摘要(Abstract):

目的 :研究脑脉通对急性局灶性脑缺血 再灌注后脑损伤的保护作用。方法 :采用线栓法建立老龄大鼠急性局灶性脑缺血 再灌注模型 ,观察缺血 3h及再灌注 12h各组神经症状、脑梗死面积、脑组织含水量、脑组织病理形态及超微结构变化。结果 :脑缺血组及脑缺血 再灌注组脑梗死面积明显大于假手术组 ,神经障碍重于假手术组 ,脑组织含水量高于假手术组 ,脑组织病理形态及超微结构改变较重。治疗组脑组织梗死面积、神经障碍、脑组织含水量、脑组织病理形态及超微结构变化较脑缺血组及脑缺血 再灌注组明显减轻 (P <0 .0 0 1)。结论 :脑脉通对局灶性脑缺血 再灌注后脑组织有保护作用
Objective: To study neuro-protective effe ct of Naomaitong on brain damage after focal cerebral ischemia reperfusion (I/R) i n the aged rats. Method: 11 groups of 20~22-month old SD rats were subjected to 3 hours of middle cerebral artery occulsion with the int raluminal filament thchnique, followed by 12 hours of referfusion. Nervous sympt on, oedema of brain, infact size, morphology and superfine structure of brain, e ct were monitored thoughout cerebral ischemia and reperfusion. Resul t: Infact size of brain in ischemia and reperfusion groups were signi ficantly greater. Oedema of it was higher, nervous sympton of it was more seriou s, and morphology and superfine structure of brain were more obvious than those of sham-operated group. Nervous sympton, oedema of brain, infact size, morpholo gy and superfine structure of brain in treated groups were ligher than those of untreated groups(P<0.001). Conclusion: Naomaitong ca n protect brain damage after focal cerebral I/R in the aged rats.

关键词(KeyWords): 老年;脑脉通;脑缺血;超微结构;神经保护
aged; cerebral ischemia; naomaitong; superf ine structure; neuro-protective effect

Abstract:

Keywords:

基金项目(Foundation): 河南省杰出青年科学基金项目(041200080 0;01120013000);; 河南省高校创新人才基金项目(200010)

作者(Author): 任小巧,李建生,封银曼,卢跃卿
REN Xiao-qiao, LI Jian-sheng, FENG Yin-man, LU Yue-qing (Henan College of Traditional Chinese Medincine, Zhengzhou 450008, Chi na)

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