中国中药杂志

2019, v.44(15) 3187-3194

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网络药理学在民族药研究中的应用与展望
Advances on network pharmacology in ethnomedicine research

黄美雯;杨华杰;周晓春;戈福星;焦顺刚;屠鹏飞;谢媛媛;柴兴云;
HUANG Mei-wen;YANG Hua-jie;ZHOU Xiao-chun;GE Fu-xing;JIAO Shun-gang;TU Peng-fei;XIE Yuan-yuan;CHAI Xing-yun;School of Chinese Materia Medica,Beijing University of Chinese Medicine;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine;School of Traditional Chinese Medicine,Guangdong Pharmaceutical University;

摘要(Abstract):

民族药是我国少数民族在与疾病斗争过程中留下的宝贵财富,与狭义的中药类似,具有多成分、多靶点、多途径协同作用特征。在民族医药理论指导下,将网络药理学用于民族药基础研究,将有助于动态性和整体性理解民族药防病治病的作用本质。该文着重综述网络药理学应用于民族药的研究进展,剖析现阶段网络药理学在民族药研究中应用存在的数据信息不够准确、缺乏有效分析各化学成分量效关系生物网络的网络分析平台及民族药前期基础研究薄弱等问题和挑战,并提出相应的展望。
Ethnomedicine is the precious wealth left by ethnic minorities in their struggle against diseases. It is similar to traditional Chinese medicine in a narrow sense and has the characteristics of multi-component,multi-target and multi-channel synergy. Under the guidance of the theory of ethnomedicine,the combination of ethnomedicine and network pharmacology will help to understand the essence of the prevention and treatment of ethnomedicines in a dynamic and holistic manner. This paper reviews the research progress of network pharmacology applied in ethnomedicine,analyses the problems and challenges existing in the application of network pharmacology in ethnomedicine research at present,such as inaccurate data and information,lack of network analysis platform for effective analysis of dose-effect relationship of chemical constituents and weak basic research of ethnomedicine,and puts forward corresponding prospects.

关键词(KeyWords): 网络药理学;民族药;药效物质基础;系统生物学;作用机制
network pharmacology;ethnomedicine;effective material basis;systems biology;mechanism of action

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基金项目(Foundation): 国家自然科学基金项目(81473174,81774001)

作者(Author): 黄美雯;杨华杰;周晓春;戈福星;焦顺刚;屠鹏飞;谢媛媛;柴兴云;
HUANG Mei-wen;YANG Hua-jie;ZHOU Xiao-chun;GE Fu-xing;JIAO Shun-gang;TU Peng-fei;XIE Yuan-yuan;CHAI Xing-yun;School of Chinese Materia Medica,Beijing University of Chinese Medicine;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine;School of Traditional Chinese Medicine,Guangdong Pharmaceutical University;

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