中国中药杂志

2000, (05)

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

防风色原酮甙类成分的药理活性研究
A Pharmacodynamic Research on Chromone Glucosides of Fangfeng

薛宝云,李文,李丽,肖永庆
XUE Bao-yun, LI Wen, LI-Li, XIAO Yong-qing (Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China)

摘要(Abstract):

目的 :观察防风两种色原酮甙类成分升麻甙和 5 O 甲基维斯阿米醇甙的药理作用。方法 :采用酵母致热法、醋酸致痛法、温热致痛法及二甲苯致炎法分别研究了其镇痛、抗炎作用。结果 :升麻甙和 5 O 甲基维斯阿米醇甙可降低大鼠体温 ,使醋酸扭体数减少 ,提高温热痛阀 ,减轻二甲苯引起的耳肿胀 ,对ADP诱导的血小板聚集有明显的抑制作用。结论 :升麻甙和 5 O 甲基维斯阿米醇甙均具有明显的解热、镇痛、抗炎及抗血小板聚集作用。
Objective: To investigate the pharmacological activity of prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol con tained in Fangfeng.Methods: Analgesic, antipyretic and antiinflammatory effects were assessed using the models of yeast-induced rat fever, acetic acidinduced peritoneal pain thermal-pain, and dimethylbenzol-induced mouse ear edema. Results: Prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol could reduce the body temperature of rats in a model of yeast induced fever. Both components could decrease the spasm action induced by peritoneal injection of acetic acid, increase the pain-threshold in a thermal-pain model, relieve the mouse ear edema caused by dimethybenzol and significantly inhibit ADP-induced platelet aggregation. Conclusion: Prim-O-glucosylcimifugin and 4'-O-β-D-glucosyl-5-O-methylvisamminol have significant analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation actions.

关键词(KeyWords): 防风;解热;镇痛;抗炎
Fangfeng; antipyretic; analgesic; antiinflammation.

Abstract:

Keywords:

基金项目(Foundation): “九五”国家科技攻关项目! ( 96 90 3 0 2 0 2 )

作者(Author): 薛宝云,李文,李丽,肖永庆
XUE Bao-yun, LI Wen, LI-Li, XIAO Yong-qing (Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享