中国中药杂志

2015, v.40(12) 2272-2277

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利水中药功效发挥与水通道蛋白之间的关系
Relationship between efficacy exertion of diuretic traditional Chinese medicines and aquaporin

王鹏程;赵珊;王秋红;匡海学;
WANG Peng-cheng;ZHAO Shan;WANG Qiu-hong;KUANG Hai-xue;Key Laboratory of Chinese Materia Medica under Ministry of Education,Heilongjiang University of Chinese Medicine;

摘要(Abstract):

近年来,水通道蛋白的发现及其研究使人们对"水"代谢的生理及病理过程有了更加深入的了解;并且长期以来,对于"利水中药"的研究缺乏分子层面的靶点,难以进行深入的、定量化的研究;而水通道蛋白的发现成为诠释"利水中药"发挥其功效机制的新的靶分子。通过水通道蛋白,可以理解中药"利水"功效的内在涵义,还可以对"利水"这一作用进行量化研究。目前,众多学者已经运用水通道蛋白研究成果在中医药领域开展了一系列的研究,并且取得了一定的进展。该文通过水通道蛋白这一靶分子来探讨"利水"中药功效的发挥做一综述。
In recent years,the discovery and studies on aquaporin have made us have a more in-depth understanding about the physiological and pathological processes of water metabolism. Over years,however,there has been no quantitative study on the target sites of diuretic traditional Chinese medicines at the molecular level. In that case,aquaporin was found to been a new target molecule to explain the efficacy exertion of diuretic traditional Chinese medicines. By studying aquaporin,researchers can understand the implicit meaning of the diuretic effect of traditional Chinese medicines and conduct quantitative studies on the diuretic effect. So far,many scholars have conducted a series of studies in the traditional Chinese medicine field by using the findings on aquaporin and made certain advances. This article provides a summary about the efficacy exertion of diuretic traditional Chinese medicines through target molecule aquaporin.

关键词(KeyWords): 中药;利水;水通道蛋白
traditional Chinese medicine;diuretic;aquaporin

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基金项目(Foundation): 国家重点基础研究发展计划(973)项目(2013CB531801)

作者(Author): 王鹏程;赵珊;王秋红;匡海学;
WANG Peng-cheng;ZHAO Shan;WANG Qiu-hong;KUANG Hai-xue;Key Laboratory of Chinese Materia Medica under Ministry of Education,Heilongjiang University of Chinese Medicine;

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