王玲燕;夏欢;夏桂阳;卫晓红;田贵华;林生;
WANG Ling-yan;XIA Huan;XIA Gui-yang;WEI Xiao-hong;TIAN Gui-hua;LIN Sheng;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine;

• 1:中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室
• 2:北京中医药大学东直门医院中医内科学教育部和北京市重点实验室

摘要(Abstract)：

疼痛是机体对有害刺激的一种保护性防御反应,长期疼痛不仅严重影响患者的躯体,给病人带来极大的痛苦,也给病人家庭和社会带来巨大的经济负担,已成为当今困扰人类健康最严重的问题之一。临床上常用的阿片类和非甾体抗炎类镇痛药(NSAIDs)等对肾脏、肝脏、心血管或胃肠道系统会产生不良反应并存在药物滥用的问题,因此,研发毒副作用小、效果显著的新型镇痛药物一直是药物学家追求的目标。天然产物是创新药物的重要来源,如延胡索乙素、草乌甲素等已作为临床一线药物广泛用于各种疼痛的治疗。前期已对天然生物碱类镇痛成分进行了综述,但在此过程中也发现一些具有镇痛活性的天然非生物碱成分。该文旨在对具有镇痛活性的天然非生物碱类成分进行综述,以期为扩大基于天然产物的镇痛药物的研发提供参考。
Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses. The commonly used opioid and non-steroidal anti-inflammatory analgesics(NSAIDs) may cause adverse reactions to the kidney, liver, cardiovascular or gastrointestinal system and cause problems of drug abuse. Therefore, it is necessary to study new analgesic drugs with less side effects and significant analgesic effects. A variety of natural products derived from terrestrial plants, microorganisms, marine organisms and fungi have been an important source of clinical medicines and provide an inexhaustible resource for the development and innovation of modern medicines. Therefore, this paper mainly reviews the natural non-alkaloids with analgesic activity in order to provide reference for the research and development of analgesic drugs derived from natural products.

关键词(KeyWords)： 疼痛;天然产物;镇痛;非生物碱;萜类;黄酮;香豆素
pain;natural products;analgesic;non-alkaloids;terpenes;flavonoids;coumarins

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81773589,81903489,81522050)

作者(Author): 王玲燕;夏欢;夏桂阳;卫晓红;田贵华;林生;
WANG Ling-yan;XIA Huan;XIA Gui-yang;WEI Xiao-hong;TIAN Gui-hua;LIN Sheng;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20201104.201

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