中国中药杂志

2019, v.44(15) 3358-3364

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雷公藤多苷片治疗类风湿关节炎骨破坏的系统评价和Meta分析
Effect of Tripterygium Glycosides Tablets in treating rheumatoid arthritis:a systematic review and Meta-analysis

朱光昭;韩晓晨;王翰洲;杨豫正;高扬;王海隆;
ZHU Guang-zhao;HAN Xiao-chen;WANG Han-zhou;YANG Yu-zheng;GAO Yang;WANG Hai-long;Beijing University of Chinese Medicine;Beijing Fengsheng Hospital of Traditional Chinese Medicine Orthopedics;Guiyang University of Chinese Medicine;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;

摘要(Abstract):

系统评价雷公藤多苷片治疗类风湿性关节炎(RA)骨破坏的影响,为雷公藤多苷片的临床应用提供循证医学证据。通过计算机与手工检索EMbase,PubMed,Clinical Trials,Web of Science,Cochrane Library,中国知网(CNKI),万方数据库(Wan Fang)、维普数据库(VIP)、中国生物医学文献数据库(CBM)和中国临床试验注册中心(Chi CTR),选择符合纳入标准的文献,按Cochrane系统评价方法,采用Rev Man 5. 3软件对雷公藤多苷片治疗类风湿关节炎患者的手腕部27个关节区骨破坏评分(Sharp)进行分析,对符合纳入标准的临床研究进行资料提取和质量评价后,3篇随机对照试验文献被纳入评价。Meta分析的结果显示,在Van der Heijde改良Sharp评分(m TSS)、关节侵蚀(JE)和关节间隙狭窄(JSN)方面,雷公藤多苷片组均优于对照组中使用的阳性药物甲氨蝶呤(MTX)和柳氮磺吡啶(SSZ),且差异有统计学差异(P<0. 01)。现有临床证据表明,雷公藤多苷片可以有效延缓类风湿关节炎的骨破坏,但由于研究样本量较少,期望将来更高质量大样本随机、对照、双盲试验提供更高级别证据。
To evaluate the effect of Tripterygium Glycosides Tablets extract in the treatment of rheumatoid arthritis( RA). Clinical trials of treating rheumatoid arthritis with Tripterygium Glycosides Tablets published by Meta-analysis were retrieved from EMbase,PubMed,Clinical Trials,Web of Science,Cochrane Library,CNKI,Wanfang,VIP,CBM and Chi CTR,and comprehensively analyzed. A total of 3 studies were enrolled,the modified Sharp score( m TSS),tender join joint erosions( JE) and joint space narrowing( JSN) of Tripterygium Glycosides Tablets group were significant superior to those of control group,including positive drugs methotrexate( MTX) and salazopyridine( SSZ)( P<0. 01). Tripterygium Glycosides Tablets had an effect in treating RA. Due to the small sample size,this study shall be verified with high-quality,large-sample-size double-blinded RCTs.

关键词(KeyWords): 雷公藤多苷片;类风湿关节炎;骨破坏;Meta分析
Tripterygium Glycosides Tablets;rheumatoid arthritis;radiological progression;Meta-analysis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(81673804);; 人社部留学人员科技活动择优项目(优秀类)(31470962);; 中央级公益性科研院所基本科研业务费专项中国中医科学院基本科研业务费自主选题项目(ZZ0708079)

作者(Author): 朱光昭;韩晓晨;王翰洲;杨豫正;高扬;王海隆;
ZHU Guang-zhao;HAN Xiao-chen;WANG Han-zhou;YANG Yu-zheng;GAO Yang;WANG Hai-long;Beijing University of Chinese Medicine;Beijing Fengsheng Hospital of Traditional Chinese Medicine Orthopedics;Guiyang University of Chinese Medicine;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;

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