中国中药杂志

2015, v.40(12) 2278-2284

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葛根素心血管保护作用及其机制研究进展
Progress on cardiovascular protections and mechanism research of puerarin

魏述永;
WEI Shu-yong;Southwest University,Rongchang Campus;

摘要(Abstract):

葛根素为传统中药葛根及粉葛的主要药效成分之一,具有典型的雌激素样生物学活性,在体内外试验中均表现出显著的心血管保护作用。研究发现,葛根素可以影响Na+,K+,Ca2+跨膜转运而改善心肌细胞膜电位及心律失常,并具有抗心肌纤维化损伤、舒张血管、抗动脉钙化及粥样硬化、促血管新生、改善微血流、抗血小板凝集、降脂、抗糖尿病等作用,其机制主要为改善心肌细胞离子流动,并减轻炎症、氧化应激及细胞凋亡所引起的心血管损伤,所调控的主要靶标为PI3K/Akt,NF-κB及caspase等信号通路。
Puerarin is one of the most important effective components of Pueraria lobata which exhibited classic estrogen-like biological activities and had remarkable cardiovascular protections in vivo and in vitro experiments. These protections of puerarin are mainly exhibited on improving the myocardial cells membrane potential and arrhythmia based on effecting the Na+,K+,and Ca2 +channels,resisting myocardial fibrosis damage,diastolic effect on blood vessels,promoting angiogenesis,resisting calcification and atherosclerosis,improving blood flow,antiplatelet aggregation,reducing lipid and resisting diabetes. The main mechanisms are to improve the membrane potential and reduce cardiovascular damage caused by inflammation,oxidative stress and apoptosis,and the main regulated signal pathways are the PI3 K / Akt,the NF-kappa B and the caspases.

关键词(KeyWords): 葛根素;心血管;保护;机制
puerarin;cardiovascular;protection;mechanism

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基金项目(Foundation): 国家自然科学基金项目(31402237);; 重庆市基础与前沿研究计划项目(cstc2014jcyj A80023);; 教育部中央高校基本科研业务费项目(XDJK2014C058)

作者(Author): 魏述永;
WEI Shu-yong;Southwest University,Rongchang Campus;

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