中国中药杂志

2020, v.45(19) 4766-4775

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

天智颗粒治疗血管性认知障碍疗效与安全性系统评价和Meta分析
Systematic evaluation and Meta-analysis of efficacy and safety of Tianzhi Granules in treatment of vascular cognitive impairment

胡文悦;韩振蕴;马华萍;林景峰;常泽;
HU Wen-yue;HAN Zhen-yun;MA Hua-ping;LIN Jing-feng;CHANG Ze;Beijing University of Chinese Medicine;

摘要(Abstract):

天智颗粒具有平肝息风、补肝肾活血作用,目前应用于治疗血管性认知障碍,但其疗效及安全性有待验证,故该研究对天智颗粒治疗血管性认知障碍的疗效与安全性进行系统评价及Meta分析。计算机检索中国期刊全文数据库(CNKI)、维普中文科技期刊数据库(VIP)、万方数据库(WanFang)、中国生物医学文献服务系统(SinoMed)、PubMed、Cochrane Library、ClinicalTrials.gov,由2名研究者独立按照纳排标准筛选天智颗粒治疗血管性认知障碍的随机对照试验,评估偏倚风险并提取、核对数据,使用RevMan 5.3完成Meta分析。纳入27篇文献,共包含2 741例患者,治疗组干预措施为天智颗粒单药,对照组为不同机制促智类或改善脑血流类西药单药,或仅行基础治疗的空白对照。结果表明,天智颗粒在临床有效率、改善MMSE评分上优于空白组与脑代谢功能促进剂组,且对事件电位P300改善作用优于空白组及尼莫地平组,天智颗粒在3个月内临床有效率、改善MMSE评分优于西药组及空白组,不良事件发生率较低,临床可考虑使用。该研究纳入文献质量均不高,未来需大样本、符合规范的高质量临床试验进一步加以证实。
Tianzhi Granules has effects in calming liver wind, nourishing liver and kidney and activating blood. At present, it is used for treatment of vascular cognitive impairment. However, its efficacy and safety remained to be verified. Therefore, this study aims to systematically analyze the efficacy and safety of Tianzhi Granules in the treatment of vascular cognitive impairment. CNKI, VIP, WanFang, SinoMed, PubMed and Cochrane Library, ClinicalTrials.gov were retrieved to screen out relevant randomized controlled trials about the effect of Tianzhi Granules on vascular cognitive impairment according to the inclusion criteria. Two researchers independently used the risk of bias assessment tool for quality assessment, and extracted and checked the data. Cochrane systematic evaluation software RevMan 5.3 was used for data analysis. Twenty-seven articles involving 2 741 subjects were included. The intervention measure was Tianzhi Granules alone, and the control measure was Western medicine alone or blank control. According to the results, Tianzhi Granules was better than blank control and brain metabolism promoter in clinical efficacy rate and improvement of MMSE score. And it was better than blank control and nimodipine in the improvement of event-related potential(ERP) P300. Within 3 months, Tianzhi Granules had better effects than Western medicine group and blank group, with a low incidence of adverse events. Tianzhi Granules can be recommended for clinical use. However, due to the low quality of the include literatures, these potential benefits need to be confirmed in future standardized clinical trials with a large sample size.

关键词(KeyWords): 天智颗粒;血管性认知障碍;系统评价;Meta分析
Tianzhi Granules;vascular cognitive impairment;systematic review;Meta-analysis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81673910)

作者(Author): 胡文悦;韩振蕴;马华萍;林景峰;常泽;
HU Wen-yue;HAN Zhen-yun;MA Hua-ping;LIN Jing-feng;CHANG Ze;Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200309.501

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享