中国中药杂志

2004, (06)

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参藿口服液药理作用的初步研究
Primary research of pharmacological effects of PEC on mice

王立为,刘新民,吕光华,高南南,肖培根
WANG Li-wei 1, LIU Xin-min 1, LU Guang-hua 2, GAO Nan-nan 1, XIAO Pei-gen 1(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100094,China; 2.College of Pharmacy,Medical University of West China, Chengdu 610044,China )

摘要(Abstract):

目的 :利用小鼠研究参藿口服液的初步药理作用。方法 :游泳、避暗、自主活动度和睡眠实验。结果 :参藿口服浓缩液 5~ 10mL·kg-1连续口服给药 7d ,能明显延长小鼠负重游泳时间 ,增加小鼠耐缺氧生存时间 ,对剥夺睡眠小鼠所引起的学习记忆障碍也有一定的改善作用 ;参藿口服浓缩液 5~ 2 0mL·kg-1连续口服给药 10d ,可明显增加正常小鼠的自主活动度 ,并能对抗安定所致的镇静作用 ,缩短戊巴比妥钠的睡眠时间。结论 :参藿口服液对小鼠具良好的抗疲劳、抗应激、增强学习记忆等药理作用。
Objective: To study pharmacological effects of PEC(the oral liquid which consists of Panax quinquefolium,Epimedium brevicornum,Schisandra chinensis Bail and Cervus eplaphus)on mice. Method: Experiments were carried out through swimming test,step-through,spontaneous activity and sleeping time. Result: When 5 ~10 mL·kg -1 of PEC was given orally for 7 days,it could prolong swimming duration of mice in water tank,and increase the tolerant ability against oxygen-deficiency. PEC could also improve cognitive-deficiency induced by taking off sleep with force in mice after given orally for 7 days. The PEC could increase the spontaneous activity in mice,antagonize the inhabitation induced by Valium,and shorten the sleeping time caused by sodium pentobarbital. Conclusion: PEC has strong potential neuro-pharmacological activities such as anti-fatigue,improving cognitive-deficiency in mice.

关键词(KeyWords): 参藿口服液;药理作用;小鼠
oral liquid of Panax quinquefolium; Epimedium brevicornum;Schisandra chinensis and Cervus eplaphus;pharmacological effects;mice

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作者(Author): 王立为,刘新民,吕光华,高南南,肖培根
WANG Li-wei 1, LIU Xin-min 1, LU Guang-hua 2, GAO Nan-nan 1, XIAO Pei-gen 1(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100094,China; 2.College of Pharmacy,Medical University of West China, Chengdu 610044,China )

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