中国中药杂志

2021, v.46(06) 1345-1356

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细胞程序性死亡与心肌缺血再灌注损伤的关系及中医药干预新视角
Relationship between programmed cell death and myocardial ischemia-reperfusion injury and new perspectives of traditional Chinese medicine intervention

谢延峥;马金;姚耿圳;邹旭;
XIE Yan-zheng;MA Jin;YAO Geng-zhen;ZOU Xu;the Second Affiliated Hospital of Guangzhou University of Chinese Medicine;Guangdong Provincial Key laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases;

摘要(Abstract):

心肌缺血再灌注损伤(MIRI)是临床治疗中亟待解决的问题。心肌细胞为终末细胞,MIRI导致的心肌细胞死亡会不可逆地损伤心脏的结构和功能。在既往研究中,细胞凋亡被认为是唯一受调控的细胞死亡方式,而细胞坏死不受调控。然而,目前研究表明,细胞坏死也可以被调控,统称为细胞程序性死亡(PCD)。由于受调控的细胞死亡通过分子途径主动介导,因此存在抑制这种信号传递的可能性,从而减轻MIRI。目前,PCD主要包括凋亡、自噬、程序性坏死,焦亡和铁死亡。中医药作为我国独特的瑰宝,在治疗疾病方面具有多通路、多靶点、毒副作用小且经济成本低等优势。随着中医药抗MIRI疗效的深入研究,证实中医药能够通过调控PCD来减轻MIRI。因此,该文通过探讨PCD与MIRI的关系,以及相关中医药对其干预的新研究,旨在从"干预PCD"角度为防治MIRI提供新视角。
Myocardial ischemia-reperfusion injury(MIRI) is an urgent problem in clinical treatment. As cardiomyocytes are terminal cells, MIRI-induced cardiomyocyte death will irreversibly damage the structure and function of the heart. In previous studies, apoptosis was considered to be the only way to regulate cell death, while necrosis could not be regulated. However, current studies have shown that cell necrosis could also be regulated, which was collectively called programmed cell death(PCD). Regulated cell death is actively mediated through molecular pathways, so there is the possibility of inhibiting this signaling to reduce MIRI. At present, PCD mainly includes apoptosis, autophagy, necrosis, pyroptosis and ferroptosis. As a unique treature in China, traditional Chinese medicine has the advantages of multiple pathways, multiple targets, low toxicity, less side effects and low economic costs. With the in-depth study of the efficacy of traditional Chinese medicine against MIRI, it has been confirmed that traditional Chinese medicine could regulate PCD to reduce MIRI. Therefore, this paper focuses on the relationship between PCD and MIRI, and new studies on intervention with relevant traditional Chinese medicine, with the aim to provide new MIRI prevention and treatment methods from the perspective of "intervention of PCD".

关键词(KeyWords): 心肌缺血再灌注损伤;细胞程序性死亡;中医药
myocardial ischemia-reperfusion injury;programmed cell death;traditional Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 广东省基础与应用基础研究基金项目(2019A1515010808,2019B1515120040);; 广东省中医药局项目(粤中医办函[2020]1号);; 广东省中医院中医学术流派传承工作室建设项目(中医二院[2013]233号);; 广东省中医院中医药科学技术研究专项(YN2019MJ10,YN2018MJ02)

作者(Author): 谢延峥;马金;姚耿圳;邹旭;
XIE Yan-zheng;MA Jin;YAO Geng-zhen;ZOU Xu;the Second Affiliated Hospital of Guangzhou University of Chinese Medicine;Guangdong Provincial Key laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases;

Email:

DOI: 10.19540/j.cnki.cjcmm.20201222.601

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