中国中药杂志

2020, v.45(24) 5917-5928

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

木香的萜类成分与药理作用研究进展
Research progress on terpenes and pharmacological effects of Saussurea lappa

王阳;范潇晓;杨军;王梓琴;王宁;陈佳琪;刘长鑫;马晓静;高小力;屠鹏飞;柴兴云;
WANG Yang;FAN Xiao-xiao;YANG Jun;WANG Zi-qin;WANG Ning;CHEN Jia-qi;LIU Chang-xin;MA Xiao-jing;GAO Xiao-li;TU Peng-fei;CHAI Xing-yun;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

摘要(Abstract):

木香原产于印度,现主产于我国云南、四川等地,是我国藏族等少数民族地区常用药材之一,具有行气止痛、健脾消食之功效,临床主要用于脾胃气滞证、泻痢、里急后重等肠胃疾病。从木香中报道了萜类、苯丙素类、木脂素类、黄酮类等化合物200余个,萜类尤其倍半萜类成分受重点关注,从化合物的数量上看,桉烷型为主,愈创木烷型、吉马烷型等也多有报道;药理活性研究涉及到提取物、挥发油和以去氢木香内酯为首要代表的单体成分,在抗肿瘤、抗炎、作用于消化系统、抗菌等方面多受关注。然而,木香来源复杂,临床应用广泛,相关化学成分和药理活性研究进展较为缺乏,该文针对木香中的萜类成分与木香的药理作用做系统总结,为进一步研究和临床应用提供参考。
Saussurea lappa originates in India, and now mainly grow in Yunnan, Sichuan and other places in China. It is one of the commonly used traditional herbal medicines in Tibet and other minority regions, with effects in regulating qi to relieve pain and invigo-rating spleen to promote food. It has been used in clinic for gastrointestinal diseases, such as Qi stagnation syndrome of spleen and stomach, diarrhea and tenesmus. More than 200 compounds have been identified from S. lappa. Among them, sesquiterpenoids attracted much attention. In terms of the number of compounds, eudesmanetype is dominant, guaiane and germacranetypes have also been reported frequently. Pharmacological studies have involved extracts, volatile oils and monomeric components represented by dehydrocostus lactone. Anti-tumor, anti-inflammatory and anti-bacterial effects on digestive system have attracted great attention. However, due to the complex sources of S. lappa and widely used in clinical practice, there is few research progress on relevant chemical constituents and pharmacological activities. This paper systematically summarizes terpenes and the pharmacological effects of S. lappa, in order to provide basis for further studies and clinical applications.

关键词(KeyWords): 木香;风毛菊属;化学成分;药理作用;综述
Saussurea lappa;Saussurea;chemical constituent;pharmacological effect;review

Abstract:

Keywords:

基金项目(Foundation): 中国民族医药学会科研项目(2019KYXM-M202-112);; 国家自然科学基金项目(81473426)

作者(Author): 王阳;范潇晓;杨军;王梓琴;王宁;陈佳琪;刘长鑫;马晓静;高小力;屠鹏飞;柴兴云;
WANG Yang;FAN Xiao-xiao;YANG Jun;WANG Zi-qin;WANG Ning;CHEN Jia-qi;LIU Chang-xin;MA Xiao-jing;GAO Xiao-li;TU Peng-fei;CHAI Xing-yun;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

Email:

DOI: 10.19540/j.cnki.cjcmm.20200903.601

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享