中国中药杂志

2020, v.45(14) 3395-3406

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中药有效成分抗肝癌作用机制研究进展
Research progress on anti-hepatocellular carcinoma mechanism of active ingredients of traditional Chinese medicine

张宇;陈华国;赵超;龚小见;周欣;
ZHANG Yu;CHEN Hua-guo;ZHAO Chao;GONG Xiao-jian;ZHOU Xin;Natural Medicine Quality Control Center, Guizhou Provincial Laboratory for Pharmaceutical Quality Control and Evaluation Technology Engineering, Guizhou Province Key Laboratory of Mountain Environmental Information System and Ecological Environment Protection, Guizhou Normal University;

摘要(Abstract):

据最新数据显示,我国肝癌的年死亡率在恶性肿瘤死亡顺位中占第2位,在城市和农村中成为致死的最主要癌症之一。该文从抗肝癌的相关中药有效成分出发,对国内外相关文献进行归纳总结,以期为抗肝癌中药药物的研发提供理论参考。结果表明,以中药提取物,黄酮类,多糖,生物碱,皂苷,挥发油,萜类,醌类,酚类,生物酶,蛋白组分等中药有效成分为切入点,主要通过抑制癌细胞增殖,阻滞癌细胞周期,抑制癌细胞侵袭和转移的能力,调节信号通路,调节血管内皮生长因子(VEGF)及活性氧簇(ROS)等发挥抗肝癌功效,可见中药有效成分对肝癌具有多层次、多目标以及相互协调的干预效应,有望成为治疗肝癌的理想型药物。
According to the latest data, the annual mortality rate of liver cancer in China ranks the second among malignant tumors, and it has become one of the most fatal cancers in urban and rural areas. This article starts with the active ingredients of traditional Chinese medicines for liver cancer to summarize the relevant literature at home and abroad, with the hope to provide theoretical references for the development of traditional Chinese medicines against liver cancer. The results show that the active ingredients of traditional Chinese medicines such as Chinese herbal extracts, flavonoids, polysaccharides, alkaloids, saponins, volatile oils, terpenes, quinones, phenols, bioenzymes, and protein components are the entry points, mainly by inhibiting the proliferation of cancer cells, blocking the cancer cell cycle, inhibiting the invasion and metastasis of cancer cells, regulating signal pathways, regulating vascular endothelial growth factor(VEGF) and reactive oxygen species(ROS), etc. to play the effects against liver cancer. It can be seen that the active ingredients of traditional Chinese medicine with coordinated intervention effects at multiple levels and multiple targets are expected to become ideal medicines for the treatment of liver cancer.

关键词(KeyWords): 肝癌;中药;有效成分;作用机制
liver cancer;traditional Chinese medicine;active ingredients;mechanism of action

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基金项目(Foundation): 国家自然科学基金项目(81860738);; 贵州省高层次创新人才培养项目(黔科合人才(2015)4033号);; 贵州省优秀青年科技人才项目(黔科合平台人才[2017]5625);; 学术新苗培养及创新探索专项(黔科合平台人才[2018]5769-27)

作者(Author): 张宇;陈华国;赵超;龚小见;周欣;
ZHANG Yu;CHEN Hua-guo;ZHAO Chao;GONG Xiao-jian;ZHOU Xin;Natural Medicine Quality Control Center, Guizhou Provincial Laboratory for Pharmaceutical Quality Control and Evaluation Technology Engineering, Guizhou Province Key Laboratory of Mountain Environmental Information System and Ecological Environment Protection, Guizhou Normal University;

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