中国中药杂志

2004, (04)

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天麻及其制剂神经保护机制的研究进展
Research progress of neuroprotective mechanisms of Gastrodia elata and its preparation

孙晓芳,王巍,王丹巧,杜贵友
SUN Xiao fang 1, WANG Wei 1, WANG Dan qiao 1, DU Gui you 2 (1.Geriatrics Institute, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091,China; 2.Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700,China)

摘要(Abstract):

天麻抗衰老和促进学习记忆的作用与其神经保护作用密切相关。研究证明 ,天麻、天麻有效成分以及天麻制剂可以通过影响兴奋性毒性、一氧化氮 (NO)系统、胶质细胞、生物膜、氧化损伤及细胞凋亡等因素起到神经保护作用。目前的研究还提示 ,抑制能量代谢障碍、抗炎和免疫调节作用可能成为天麻神经保护机制研究的新靶点。
The effects of Gastrodia elata on preventing decrepitude and advancing memory are closely associated with its neuroprotective activity. Previous researches proved that G. elata , its active components and preparations played a neuroprotective role by affecting the excitotoxicity, nitric monoxide (NO) system, neuroglia, biomembrane, oxidative neurotoxicity, apoptosis et al. Recent researches also suggest that reducing energy metabolism impairment, anti inflammatory and immune modulating function may be new research targets of neuroprotective mechanism of G. elata .

关键词(KeyWords): 天麻;神经保护
Gastrodia elata ; neuroprotection

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基金项目(Foundation): 国家自然科学基金资助项目( 3 0 171185 );; 北京自然科学基金资助项目( 70 12 0 3 3 )

作者(Author): 孙晓芳,王巍,王丹巧,杜贵友
SUN Xiao fang 1, WANG Wei 1, WANG Dan qiao 1, DU Gui you 2 (1.Geriatrics Institute, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091,China; 2.Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700,China)

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