中国中药杂志

2011, v.36(21) 2911-2915

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复方丹参方主要活性成分网络药理学研究
Network pharmacology study on major active compounds of Fufang Danshen formula

李翔;吴磊宏;范骁辉;张伯礼;高秀梅;王毅;程翼宇;
LI Xiang1,WU Leihong1,FAN Xiaohui1,ZHANG Boli2,GAO Xiumei2,WANG Yi1,CHENG Yiyu1 (1.Department of Chinese Medicine Science & Engineering,Zhejiang University,Hangzhou 310058,China; 2.State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

摘要(Abstract):

目的:采用网络药理学方法研究复方丹参方,探索其多成分-多靶点-多疾病相关关系。方法:针对方中丹参酮IIA、丹酚酸B、原儿茶醛、丹参素、隐丹参酮、三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1、龙脑等9个活性成分,依据PubMed中相关文献知识构建多成分-基因网络,进而用OMIM数据库中的心血管相关疾病-基因关系数据,采用Cytoscape软件建立多成分-多基因-多疾病网络模型。结果与结论:网络分析表明,这9个活性成分可调控PPARG,ACE,KCNJ11,KCNQ1,ABCC8等42个心血管相关疾病基因表达,涉及糖尿病、高胰岛素型低血糖症等30种疾病,提示复方丹参方具有新的临床适应症研究前景。
Objective: To investigate the correlations between multi-compounds of Fufang Danshen formula and their multi targets and multi diseases.Method: Literature knowledge of nine major active compounds from Fufang Danshen formula,including tanshinone ⅡA,salvianolic acid B,protocatechuic aldehyde,danshensu,cryptotanshinone,notoginsenoside R1,ginsenoside Rg1,ginsenoside Rb1 and borneol were collected from PubMed.Combined with cardiovascular related diseases and genes from OMIM database,the corresponding multi-compound-multi-target-multi-disease network was constructed and visualized by Cytoscape software.Result and Conclusion: Network analysis showed that the 9 compounds could modulate 42 cardiovascular associated genes(e.g.PPARG,ACE,KCNJ11,KCNQ1,ABCC8,et al),which related to 30 cardiovascular associated diseases including non-insulin-dependent diabetes mellitus,hyperinsulinemic hypoglycemia,hypertension,and coronary heart disease.These results suggested new potential indications of Fufang Danshen formula.

关键词(KeyWords): 网络药理学;复方丹参方;网络中药药理学;冠心病;糖尿病
network pharmacology;Fufang Danshen formula;network traditional Chinese medicine pharmacology;coronary heart disease;diabetes mellitus

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基金项目(Foundation): 国家自然科学基金重点项目(30830121);; 科技部国际合作项目(2009DFB03510)

作者(Author): 李翔;吴磊宏;范骁辉;张伯礼;高秀梅;王毅;程翼宇;
LI Xiang1,WU Leihong1,FAN Xiaohui1,ZHANG Boli2,GAO Xiumei2,WANG Yi1,CHENG Yiyu1 (1.Department of Chinese Medicine Science & Engineering,Zhejiang University,Hangzhou 310058,China; 2.State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

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