中国中药杂志

2020, v.45(14) 3299-3306

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

基于真实世界的肾恶性肿瘤联合用药复杂网络分析
Complex network analysis of combination medication of patients with kidney malignant tumor based in real world

赵明明;谢雁鸣;刘峘;张寅;鹿琦;庄严;
ZHAO Ming-ming;XIE Yan-ming;LIU Huan;ZHANG Yin;LU Qi;ZHUANG Yan;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;Xiyuan Hospital, China Academy of Chinese Medical Sciences;School of Statistics,Renmin University of China;Navy PLA General Hospital;

摘要(Abstract):

肾恶性肿瘤是原发性肾细胞癌的一类,主要指肾癌,目前我国肾癌发病率和医院就诊病例均呈增长趋势。基于全国37家三甲医院的医院信息系统(HIS)数据库中患者的临床用药信息,采用Tabu搜索算法对肾恶性肿瘤患者的联合用药进行复杂网络分析,以分析真实世界肾恶性肿瘤患者的联合用药方案。共纳入7 095例肾恶性肿瘤患者,男-女2.11∶1,随年龄增长,男性患者比例逐渐增大;其中,优效人群3 933例,占55.43%。肾恶性肿瘤患者的常见治疗为抗肿瘤及对症治疗,主要包括抗感染、调节电解质平衡、镇静镇痛、镇吐、调节胃肠道功能等。肾恶性肿瘤患者全人群多为抗肿瘤药物联合较多对症治疗,而优效人群抗肿瘤治疗少与其他药物联用,且联合应用药物较少,可能与肿瘤分期、对治疗方案个体反应不同有关。无论是肾恶性肿瘤全人群还是优效人群,用药均以西药为主,中药清热解毒剂、益气补血剂、理气活血剂、通便剂、止血剂的应用频次较高,为一个中药药理子集,契合肾癌本虚标实的基本病机。今后需进一步研究不同肿瘤分期患者的联合用药方案,发挥中医药多靶点、整体调节、减毒增效等作用优势,提高肾癌患者的生活质量、延长其生存期,提高患者的生存率。
Kidney malignant tumor is a type of primary renal cell carcinoma, and mainly refers to renal cancer. The incidence of kidney cancer and the number of hospital cases in China have been increasing. Based on the clinical medicine information of patients in the hospital information system(HIS) database of 37 hospitals in China, the combined medication of patients with kidney malignant tumor were analyzed by Tabu search algorithm, so as to analyze the combined medication of patients with kidney malignant tumor in real world. A total of 7 095 patients with kidney malignant tumor were included, the ratio of males to females was 2.11∶1, and the ratio of male patients increased gradually with age. About 3 933 patients(55.43%) showed a superior effect among those patients. The common therapies of patients with kidney malignant tumor were anti-tumor therapies and symptomatic therapies, including anti-infection, regulation of electrolyte balance, sedation and analgesia, analgesic, regulation of gastrointestinal function. The whole population of patients with kidney malignant tumor were mostly treated with anti-tumor drugs combined with more symptomatic therapies, while the anti-tumor therapies of the superiority population of patients were less combined with other drugs, with less combined medication. The result may be related to the stage of tumor or individual response to the therapeutic regimen. No matter for the whole population or for the superiority population of patients with kidney malignant tumor, the therapies was mainly Western medicines. Based on the pathogenesis of deficiency in origin and excess in superficiality with kidney malignant tumor, Chinese subgroups with formula for clearing heat and removing toxicity, formula for vigorate Qi and replenish the blood, formula for regulate Qi and invigorate the blood, laxative and hemostatic were more commonly used. In the future, further studies shall be conducted for combined therapies for patients of different stages, so as to play the advantages of multi-target, overall regulation, toxicity reduction and efficacy enhancement of traditional Chinese medicine, improve the life quality of patients with kidney malignant tumor, prolong their life time, and improve the survival rate of patients.

关键词(KeyWords): 真实世界;肾恶性肿瘤;医院信息系统(HIS);复杂网络分析
real world;kidney malignant tumor;hospital information system(HIS);complex network analysis

Abstract:

Keywords:

基金项目(Foundation): 国家重点研发计划项目(2018YFC1707410);; 中国中医科学院自主选题项目(Z0472)

作者(Author): 赵明明;谢雁鸣;刘峘;张寅;鹿琦;庄严;
ZHAO Ming-ming;XIE Yan-ming;LIU Huan;ZHANG Yin;LU Qi;ZHUANG Yan;Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences;Xiyuan Hospital, China Academy of Chinese Medical Sciences;School of Statistics,Renmin University of China;Navy PLA General Hospital;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享