中国中药杂志

2015, v.40(23) 4609-4615

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基于数据挖掘方法研究挥发油透皮促渗作用与中药药性间的关联性
Association between penetration enhancement effect of essential oils and drug properties of traditional Chinese medicines by data mining method

杨文国;陈军;刘培;蒋秋冬;王研;周成;段金廒;
YANG Wen-guo;CHEN Jun;LIU Pei;JIANG Qiu-dong;WANG Yan;ZHOU Cheng;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine;Information Technology College,Nanjing University of Chinese Medicine;Pharmaceutical Research Laboratory,School of Pharmacy,Nanjing University of Chinese Medicine;

摘要(Abstract):

分析文献报道的中药挥发油的促渗作用与来源中药药性的相关性。通过文献调研,收集了34种具有透皮促渗作用报道的中药挥发油,采用频数分析法、变量交叉表法进行直观分析和关联分析,并通过变量压缩法建立一般线性模型分析来源中药药性(四气、五味、归经)与透皮促渗效果的关系。结果表明,具有透皮促渗效果的挥发油均来自辛味药材,阳性药性有利于中药挥发油透皮促渗;五味对于渗透效果影响不大(P=0.698 2),而四气和归经对于渗透效果影响很显著(P=0.011,0.077),四气的影响尤其大。提示中药挥发油透皮促渗作用与来源中药药性有明显的相关性和规律性。
To study the association between penetration enhancement effect of essential oils and drug properties of traditional Chinese medicines. Through literature research,34 kinds of essential oils with the penetration enhancement effect were collected. The methods of frequency analysis and variable crosstab were used for intuitive analysis and association analysis. The association between penetration enhancement effect of essential oils and drug properties( four natures,five flavors,channel tropism) were analyzed by a general linear model. According to the findings,the essential oils with penetration enhancement effect were all sourced from acrid traditional Chinese medicines,because their positive drug nature contributed to the enhancement of the penetration effect of essential oil;five flavors had little effect on penetration enhancement( P = 0. 698 2),but four natures and channel tropism showed significant effects( P = 0. 011,0. 077). In conclusion,there were obvious association and regularity between penetration enhancement effect of essential oils and drug properties of traditional Chinese medicine.

关键词(KeyWords): 中药药性;透皮促渗;中药挥发油;数据挖掘;一般线性模型
drug properties of traditional Chinese medicine;penetration enhancement effect;essential oils;data mining;general linear model

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基金项目(Foundation): 江苏省中药资源产业化过程协同创新中心重点项目(ZDXMHT-1-15);; 江苏省高校自然科学研究面上项目(14KJB360001);; 江苏省大学生创新训练计划重点项目(201510315028Z);; 江苏省高校优势学科建设工程项目(2014)

作者(Author): 杨文国;陈军;刘培;蒋秋冬;王研;周成;段金廒;
YANG Wen-guo;CHEN Jun;LIU Pei;JIANG Qiu-dong;WANG Yan;ZHOU Cheng;DUAN Jin-ao;Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,Nanjing University of Chinese Medicine;Information Technology College,Nanjing University of Chinese Medicine;Pharmaceutical Research Laboratory,School of Pharmacy,Nanjing University of Chinese Medicine;

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