中国中药杂志

2004, (07)

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前列回春对实验性大鼠前列腺组织显微结构和超微结构的影响
Effect of Qianlie Huichun capsule on microstructure and ultranstructure of prostate glandular tissues in rats

段登志,于玲,滕毅山,陈黎明,段呈玉,杨玉琪,曹继刚
DUAN Deng-zhi1, YU Ling2, TEN Yi-shan3, CHENG Li-ming1, DUAN Cheng-yu1, YANG Yu-qi1, CAO Ji-gang4 (1.Traditional Medical and Medicine Institute of Yunnan, Kunming 650223, China; 2.Center of Disease Control of Yunnan, Kunming 650011, China; 3.Medicial College of Kunming,Kunming 650118, China; 4.Hubei Traditional Chinese Medicial College,Wuhan 430061, China)

摘要(Abstract):

目的 :探讨前列回春对实验性大鼠前列腺组织显微结构和超微结构的影响。方法 :采用大鼠去势后注射丙酸睾酮引起前列腺增生法造模 ,灌胃给药 30d后 ,处死大鼠取前列腺组织用光镜和电镜观察 ,并在光镜下测量各实验组前列腺腺体管腔直径和上皮细胞高度。结果 :模型组腺上皮增生呈复层及假复层凸向管腔 ,使管腔缩小 ,管壁增厚 ,电镜下上皮细胞呈高柱状 ,粗面内织网高度扩张 ,其他各组增生不明显 ,各组前列腺腺体管腔直径和上皮细胞高度与模型组比较均有显著性差异或非常显著性差异 (P <0 .0 5 ,P <0 .0 1)。结论 :前列回春可抑制实验性大鼠前列腺组织上皮细胞增生。
Objective: To investigate the effect of Qianlie Huichun capsule on the microstructure and ultranstructure of prostate glandular tissue in the model rat. Method: Hynertophy of prostate model rat was established by injecting testosterone to gelding male rats. After having been fed with Qianlie Huichun capsule for 30 days, the rats were killed and prostate tissues were resected for pathomorphological studies with microscope and electromicroscope, and the diameter of glandular lumer and the height of glandular epithelial cells were measured under the microspcope for different groups of rats. Result: In the model groups, the glandular epithelial cells mutiplycated notably,showing stratified and pseudostratified cells that made the glandular lumer cramped. Under the electromicroscope, the glandular epithelial cells became high columnor and the rough endoreticulum extremely expanded.But in treatment groups, the change of the diameter of the glandnlar lumer and the hight of the glandular epithelial cells were less remarkable than those in model groups. So the differerence between the model group and the treatment groups was remarkable (P<0.01). Conclusion: Qianlie Huichun capsule can depress the glandular epithelialceu multiplication of prostate gland in model rats.

关键词(KeyWords): 前列回春;前列腺增生;显微结构;超微结构
Qianlie Huichun; hypertrophy of prostate; ultranstructure; micrstructure

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作者(Author): 段登志,于玲,滕毅山,陈黎明,段呈玉,杨玉琪,曹继刚
DUAN Deng-zhi1, YU Ling2, TEN Yi-shan3, CHENG Li-ming1, DUAN Cheng-yu1, YANG Yu-qi1, CAO Ji-gang4 (1.Traditional Medical and Medicine Institute of Yunnan, Kunming 650223, China; 2.Center of Disease Control of Yunnan, Kunming 650011, China; 3.Medicial College of Kunming,Kunming 650118, China; 4.Hubei Traditional Chinese Medicial College,Wuhan 430061, China)

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