中国中药杂志

2021, v.46(20) 5159-5165

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睡茄——近年来国际上流行的一种药食两用植物
Withania somnifera: a kind of food-medicine plant popular in world in recent years

王悦;杨凯琳;何春年;肖培根;
WANG Yue;YANG Kai-lin;HE Chun-nian;XIAO Pei-gen;Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medicinal College;Key Laboratory of Bioactive Substances and Resources Utilisation of Chinese Herbal Medicine, Ministry of Education;

摘要(Abstract):

茄科睡茄Withania somnifera又叫印度人参,是印度阿育吠陀医学体系中一种重要的传统药物,具有显著的适应原样作用。现代研究表明睡茄主要化学成分为睡茄内酯类成分,具有抗氧化、抗肿瘤、增强免疫、心血管保护、神经保护、抗压力、抗应激反应以及降血糖等活性。人体试验、动物实验以及致突变、遗传毒性、生殖毒性和药物相互作用等研究显示睡茄具有较好的安全性。临床试验证明睡茄对人体多种疾病疗效确切。作为一种著名的传统药物和现代膳食补充剂在国际保健品市场有较高的知名度和销售份额比例,但在我国无论在科学研究、市场开发以及产品引进和应用方面均较少。该文通过对睡茄传统应用、化学成分、药理活性、安全性评价和临床研究等方面进行了介绍,增加对该药食两用植物的了解,为将来产品引进、服务于我国人民健康和增进我国与国际健康产品贸易的"双循环"提供参考。
Withania somnifera, also known as Indian ginseng, is an important traditional medicine in the Ayurvedic medical system of India, which has a significant effect of adaptation. Modern studies have shown that the main chemical components of W. somnifera are withanolides, which have antioxidant, anti-tumor, enhancing immunity, cardiovascular protection, neuroprotection, anti-stress, anti-stress reaction and hypoglycemic activities. Studies on human, animal, mutagenesis, genotoxicity, reproductive toxicity and drug interaction showed that W. somnifera had good safety. Clinical trials have proved that W. somnifera is effective in treating a variety of human diseases. As a famous traditional medicine and modern dietary supplement, it has a high reputation and market in the international health product market, but in China, there is little scientific research, market development, product introduction and application. In this paper, the traditional application, chemical composition, pharmacological activity, safety evaluation and clinical study of the plant were introduced, so as to increase the understanding of the dual use of the plant, and to provide reference for the future introduction of the product, the service to the health of the Chinese people and the promotion of the "double cycle" of the trade of health products between China and the international community.

关键词(KeyWords): 睡茄;药食两用;化学成分;药理活性;安全性评价
Withania somnifera;food-medicine;chemical composition;pharmacological activity;safety evaluation

Abstract:

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基金项目(Foundation): 中国工程院战略研究与咨询重点项目(2021-XZ-10);; 国家“重大新药创制”科技重大专项(2018ZX09711-001)

作者(Author): 王悦;杨凯琳;何春年;肖培根;
WANG Yue;YANG Kai-lin;HE Chun-nian;XIAO Pei-gen;Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medicinal College;Key Laboratory of Bioactive Substances and Resources Utilisation of Chinese Herbal Medicine, Ministry of Education;

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