中国中药杂志

2015, v.40(23) 4560-4567

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

槲皮素及其糖苷衍生物降糖降脂活性研究进展
Hypoglycemic and hypolipidemic effects of quercetin and its glycosides

闫淑霞;李鲜;孙崇德;陈昆松;
YAN Shu-xia;LI Xian;SUN Chong-de;CHEN Kun-song;Laboratory of Fruit Quality Biology at Zhejiang University/State Agriculture Ministry Laboratory of Horticultural Plant Growth,Development and Quality Improvement;

摘要(Abstract):

槲皮素及其糖苷衍生物是中草药和果蔬等植物源食物中常见的黄酮醇类物质,具有广泛的药理活性。大量研究表明槲皮素及其糖苷衍生物对糖尿病、肥胖、高血脂等慢性非传染性疾病有一定的预防、缓解和治疗作用。该文就槲皮素及其糖苷衍生物的分类与分布、降糖降脂活性及其作用机制进行文献综述;并对将来深入研究不同槲皮素糖苷衍生物的生物活性、量效关系、构效关系、体内生物有效性及药理学机制等作了展望。
Quercetin and its glycosides are important flavonols in traditional herbal drugs and plant-derived food,and they have diverse biological activities such as antioxidant,anticarcinogenic,anti-inflammatory,hypoglycemic and hypolipidemic activities. Numerous studies have demonstrated that quercetin and its glycosides were effective in the prevention and treatment of non-infectious chronic disease such as diabetes,obesity,and hyperlipidemia. They can regulate glucose and lipid metabolism through different mechanisms.They can decrease blood glucose via protecting pancreatic β cells or / and improving insulin sensitivity. Also,they have lipid-lowering effects,which may be the result of regulation of lipid catabolism or / and anabolism. Their distributions,as well as the hypoglycemic and hypolipidemic effects are reviewed in this paper. In addition,further bioactivities as well as their dose-activity relationship,structure-activity relationship,bioavailability,and future clinical application of quercetin and its glycosides are discussed and proposed.

关键词(KeyWords): 槲皮素及其糖苷衍生物;分类分布;降糖;降脂;作用机制
quercetin and its glycosides;distribution;hypoglycemic;hypolipidemic;mechanism

Abstract:

Keywords:

基金项目(Foundation): 国家“十二五”科技支撑计划项目(2012BAD33B08);; 农业部公益性行业科研专项(201203089-2);; 国家国际科技合作专项(2014DFE30050)

作者(Author): 闫淑霞;李鲜;孙崇德;陈昆松;
YAN Shu-xia;LI Xian;SUN Chong-de;CHEN Kun-song;Laboratory of Fruit Quality Biology at Zhejiang University/State Agriculture Ministry Laboratory of Horticultural Plant Growth,Development and Quality Improvement;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享