中国中药杂志

2002, (10)

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茯苓中三萜酸类成分HPLC指纹图谱的初步研究
Study on HPLC Fingerprint of the Triterpene Acids in Poria cocos

丁岗,王振中,章晨峰,盛龙生
DING Gang1, WANG Zhen-zhong2, ZHANG Chen-feng2, SHENG Long-sheng1 (1.Center for Instrumental Analysis,China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 2.Pharmaceutical Institute, Jiangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222

摘要(Abstract):

目的 :建立茯苓中三萜酸类成分HPLC指纹图谱的测试方法。方法 :利用RP HPLC、线性梯度洗脱筛选最佳测试条件 ,并应用LC/MS技术指认指纹图谱中的主要色谱峰。结果 :获得了较为理想的茯苓三萜酸类成分HPLC指纹图谱 ,其中 9个色谱峰被指认。结论 :用文中的最佳条件可较全面地反映茯苓中的三萜酸类成分 ,为茯苓药材的质量控制提供有效手段。
Objective: To establish a method for HPLC fingerprint determination of the triterpene acids in Poria cocos. Method: RP-HPLC, linear gradient elution and LC/MS, etc. were used to optimize the fingerprint determination method, and identify the main peaks in the HPLC fingerprint. Result: A preferable method for HPLC fingerprint determination of the triterpene acids in P. cocos was established, and 9 peaks in the HPLC fingerprint were identified. Conclusion: A general acquaintance of the triterpene acids in P.cocos can be obtained by using the preferable HPLC fingerprint determination method, which is useful for quality evaluation of the crud drug of P. cocos.

关键词(KeyWords): 茯苓;三萜酸;HPLC指纹图谱
Poria cocos; triterpene acids; HPLC fingerprint

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基金项目(Foundation): 国家重点科技攻关项目 (99 92 9 0 2 0 6)

作者(Author): 丁岗,王振中,章晨峰,盛龙生
DING Gang1, WANG Zhen-zhong2, ZHANG Chen-feng2, SHENG Long-sheng1 (1.Center for Instrumental Analysis,China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 2.Pharmaceutical Institute, Jiangsu Kanion Pharmaceutical Co.,Ltd., Lianyungang 222

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