中国中药杂志

2020, v.45(16) 3776-3783

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中西药联合用药抗抑郁研究进展
Research progress in combination applications of antidepressant drugs

刘欢乐;卫拂晓;秦雪梅;刘晓节;
LIU Huan-le;WEI Fu-xiao;QIN Xue-mei;LIU Xiao-jie;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Shanxi Key Laboratory of Active Constituents Research and Utilization of Tradition Chinese Medicine;

摘要(Abstract):

抑郁症是一种常见的情感障碍疾病。抗抑郁药物是目前临床上治疗抑郁症的主要方式。由于抑郁症病因病机复杂、类型多样、伴发症状多且严重等特点,在抗抑郁药物基础上合理加用其他药物能显著提高抑郁症的治愈率、减轻不良反应、提高患者依从性。因此,联合用药是目前临床常用的治疗抑郁症的方法。该文以"抗抑郁""抑郁症""联合用药""协同""增效"为主题,检索了2010至2019近十年的相关文献600余篇。基于此,对现有的抗抑郁药物联合用药进行归纳、分类,从西药联合西药、西药联合中药、中药联合中药等3个角度系统地阐述了抗抑郁药物联合用药的现状,以期为抗抑郁临床选用合理的联合用药方案提供方向、依据。
Depression is a common affective disorder. The application of antidepressants can significantly alleviate the symptoms of depression, which is the most important way to treat depression in clinical practice. Due to the complex etiology, wide variety, as well as diversity and severity of serious concomitant symptoms, rational addition of other drugs into antidepressants can significantly improve the cure rates of depression, reduce adverse reactions, and improve patient compliances. Therefore, the combined applications of differential drugs have been commonly used in clinic. In this paper, more than 600 literatures about depression from 2010 to 2019 were collected based on the key words of antidepressant, depression, combined medication, synergism and increase efficiency. Based on this, by summarizing and classifying the existing combinations of antidepressant drugs, this paper systematically expounds the current combined applications of antidepressant drugs in three categories, i.e. western medicines combined with western medicines, western medicines combined with traditional Chinese medicines, and traditional Chinese medicines combined with traditional Chinese medicines, in the expectation of providing the direction and basis for the selection of rational combinations of antidepressant drugs in clinic.

关键词(KeyWords): 抑郁症;抗抑郁药物;联合用药;继发性抑郁症;难治性抑郁症
depression;antidepressant drugs;drug combinations;secondary depression;treatment resistant depression

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基金项目(Foundation): 国家自然科学基金青年项目(81803962)

作者(Author): 刘欢乐;卫拂晓;秦雪梅;刘晓节;
LIU Huan-le;WEI Fu-xiao;QIN Xue-mei;LIU Xiao-jie;Modern Research Center for Traditional Chinese Medicine, Shanxi University;Shanxi Key Laboratory of Active Constituents Research and Utilization of Tradition Chinese Medicine;

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