中国中药杂志

2019, v.44(20) 4405-4411

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中药谱效关系的研究方法及应用进展
Research methods and applications progress on spectrum-effect relationships in study of traditional Chinese medicine

张小艺;刘久石;高石曼;陈荣昌;齐耀东;张本刚;刘海涛;肖培根;
ZHANG Xiao-yi;LIU Jiu-shi;GAO Shi-man;CHEN Rong-chang;QI Yao-dong;ZHANG Ben-gang;LIU Hai-tao;XIAO Pei-gen;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College;

摘要(Abstract):

应用化学指纹图谱评价中药质量已被很多国家广泛接受和使用,然而,仅通过分析其化学成分的种类和含量评估中药的质量,则忽略了中药药效这一质量评价的金标准。中药谱效关系研究将中药化学成分与中药药效活性有机结合,可更全面、多角度地进行中药质量评价,已应用于中药研究的多个领域。该文主要对中药谱效关系的研究方法,及其在中药研究领域的应用进行梳理总结,为中药谱效关系的研究、发展和在更大范围的应用提供参考。
The application of chemical fingerprint to evaluate the quality of traditional Chinese medicine has been widely accepted and used in many countries. However,only by analyzing the type and content of its chemical components to evaluate the quality of traditional Chinese medicines,the gold standard of quality evaluation by evaluating pharmacodynamic effects is ignored. The study of Chinese medicinal spectrum-effect relationships combining the chemical composition with the pharmacodynamic activity of traditional Chinese medicine,which can evaluate the quality of traditional Chinese medicine from more comprehensive and different angles,has been applied in many fields of traditional Chinese medicine research. This paper mainly summarizes the research methods of the Chinese medicinal spectrum-effect relationships and its application in the field of traditional Chinese medicine study,and provides reference for the research,development and application of the Chinese medicinal spectrum-effect relationships.

关键词(KeyWords): 中药谱效关系;化学指纹图谱;药效学评价;多元统计分析
Chinese medicinal spectrum-effect relationships;chemical fingerprint;pharmacodynamic evaluation;multivariate statistical analysis

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(8167141424)

作者(Author): 张小艺;刘久石;高石曼;陈荣昌;齐耀东;张本刚;刘海涛;肖培根;
ZHANG Xiao-yi;LIU Jiu-shi;GAO Shi-man;CHEN Rong-chang;QI Yao-dong;ZHANG Ben-gang;LIU Hai-tao;XIAO Pei-gen;Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College;

Email:

DOI: 10.19540/j.cnki.cjcmm.20190429.201

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