中国中药杂志

2004, (09)

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肿瘤细胞多药耐药性与中药的逆转作用
Tumor multidrug-resistance and reversing actions of traditional Chinese medicine

丰俊东,徐晓玉
FENG Jun-dong, XU Xiao-yu(College of Traditional Chinese Medicine, Chongqing Medical University, Chongq ing, 400050, China)[

摘要(Abstract):

肿瘤细胞多药耐药 (MDR)是化疗失败的主要原因 ,近年来逆转肿瘤多药耐药的研究越来越受到重视。MDR的机制涉及P gp ,MRP1,细胞凋亡 ,DNA修复异常 ,器官微环境等 ,作者总结了MDR机制研究的新进展 ,同时总结了中药逆转MDR的研究进展 ,并讨论它们的主要特点和作用机理。
Tumor multidrug-resistance(MDR) is a majo r factor in chemotherapeutic failure. In recent years, the development of anti-MD R has become an important focus in research. The mechanisms of MDR relate to P- glycoprotein, MRP1, apoptosis, the unusual DNA repair, the organic micro-enviro ment, and so on. This review summarized the advances in MDR mechanism research. At the s ame time, it summarized the recent research of traditional Chinese medicine in reversing MDR. Furthermore, their mechanisms and major features of actions we re also discussed.[

关键词(KeyWords): 肿瘤;多药耐药;机制研究;中药
tumor; multidrug-resistance(MDR); traditio nal Chinese medicine

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基金项目(Foundation): 国家自然科学基金资助项目 ( 3 93 0 0 0 173 ;3 9470 0 5 8)

作者(Author): 丰俊东,徐晓玉
FENG Jun-dong, XU Xiao-yu(College of Traditional Chinese Medicine, Chongqing Medical University, Chongq ing, 400050, China)[

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