中国中药杂志

2008, (16) 2048-2050

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解酒肝康颗粒对酒精性脂肪肝大鼠脂质代谢影响的研究
Influences of Jiejiu Gankang granule on lipid metabolism and liver function of alcohol-fatty-liver about mice

李彬;王丽;孙蓉;
LI Bin1,WANG Li2,SUN Rong1(1.Shandong Academy of Chinese Medicine,Jinan 250014,China;2.Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

摘要(Abstract):

目的:观察解酒肝康颗粒对酒精性脂肪肝大鼠脂质代谢的影响。方法:用酒精性脂肪肝模型,观察不同剂量的解酒肝康颗粒对血脂代谢、肝内脂代谢、能量及氧化损伤程度的影响。结果:解酒肝康颗粒可使酒精性脂肪肝大鼠血甘油三酯(TG),低密度脂蛋白(LDL-C),丙二醛(MDA)水平显著降低,肝内组织内糖原(Gn),MDA含量显著降低,超氧化物歧化酶(SOD)活性显著升高。结论:其药物高、中、低剂量之间在药效作用强度上存在一定的剂量依赖关系。
Objective: Jiejiu Gankang granule had been observed the effect on the model of the alcohol-fatty-liver about mice on lipid metabolism.Method: There was the model of alcohol-fatty-liver adopted in this experiment.The effect had been observed of Jiejiu Gankang granule in different dosages on blood-lipoid metabolism,intrahepatic-lipoid metabolism,energy metabolism or and oxidative damage degree.Result: Jiejiu Gankang granule can decrease the level of TG,LDL,MDA in blood obviously.It can decrease the content of Gn,MDA and improve the level of SOD in liver obviously.Conclusion: There was some reference of dosage dependence on the intensity of potency action in high,middle and low dosage of this drug.

关键词(KeyWords): 解酒肝康颗粒;血、肝内脂代谢;能量代谢;氧化损伤
Jiejiu Gankang granule;blood-lipid metabolism;intrahepatic-lipoid metabolism;metabolism energy;oxidative damage

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基金项目(Foundation): 山东省科技攻关课题(2006GG2202065)

作者(Author): 李彬;王丽;孙蓉;
LI Bin1,WANG Li2,SUN Rong1(1.Shandong Academy of Chinese Medicine,Jinan 250014,China;2.Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

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