中药指纹图谱谱效相关性研究思路探讨Investigation of research method of fingerprint pharmacodynamics of traditional Chinese medicines
陶金华;狄留庆;文红梅;赵晓莉;单进军;蔡宝昌;
TAO Jinhua,DI Liuqing*,WEN Hongmei,ZHAO Xiaoli,SHAN Jinjun,CAI Baochang(Nanjing University of Chinese Medicine,Nanjing 210046,China)
摘要(Abstract):
中药指纹图谱在中药及制剂质量控制中具有广泛的应用,研究建立谱效相关性指纹图谱可以进一步提高指纹图谱质量控制的针对性。本研究在系统总结近年来国内外有关指纹图谱谱效相关性研究文献的基础上,分析和评价了中药谱效相关性研究思路和方法,结合实验室工作积累,探索性地提出了中药指纹图谱谱效相关性的研究思路,以期进一步推动中药指纹图谱谱效相关性研究工作的开展。
Fingerprinting techniques play an increasingly important role in the quality control standards of traditional Chinese medicines(TCM),research and establish the fingerprint about spectral-efficiency could improve the quality control of TCM.The necessity of the fingerprint pharmacodynamics research and the analysis and evaluation of the research methods in the existing literature at home and abroad were reviewed in this article,Combined with the author's laboratory research,we proposed the research methods of fingerprint pharmacodynamics of TCM and provided the basis for effectively promoting the the establishment and development of fingerprint pharmacodynamics of Chinese medicine compound preparations.
关键词(KeyWords):
中药;指纹图谱;谱效学
traditional Chinese medicines(TCM);fingerprint;fingerprint pharmacodynamics
基金项目(Foundation): 国家自然科学基金项目(30873401);; 国家科技部863计划(2003AA2Z3247);; 江苏省自然科学基金项目(BK2005150);; 江苏省“青蓝工程“科技创新团队支持计划
作者(Author):
陶金华;狄留庆;文红梅;赵晓莉;单进军;蔡宝昌;
TAO Jinhua,DI Liuqing*,WEN Hongmei,ZHAO Xiaoli,SHAN Jinjun,CAI Baochang(Nanjing University of Chinese Medicine,Nanjing 210046,China)
Email:
DOI:
参考文献(References):
- [1]Bauer R.Quality criteria and phytopharmaceutical:Can accepta-ble drug standards be achieved[J].Drug Infor J,1998,32:101.
- [2]Lazarowych N.Use of fingerpriting and marker compounds foridentification and standardization of botanical drugs strategies forapplying pharmaceutical HPLC analysis to herbal products[J].Drug Infor J,1998,32:497.
- [3]谢培山.银杏叶标准提取物EGb761OR及银杏叶制剂的质量评价(续完)[J].中国中药杂志,1999,24(2):116.
- [4]李戎,闫智勇,李文军,等.创建中药谱效关系学[J].中医教育,2002,21(2):62.
- [5]罗国安,王义明,曹进,等.建立我国现代中药质量标准体系的研究[J].世界科学技术———中医药现代化,2002,4(4):5.
- [6]宁黎丽,毕开顺,王瑞,等.吴茱英汤药效物质基础的方法学研究[J].药学学报,2000,35(2):131.
- [7]钱俊,尹莲.加味四妙丸有效部位群HPLC指纹图谱归属分析及谱效关系研究[J].世界科学技术———中医药现代化,2007,9(1):40.
- [8]刘荣华,余伯阳,陈兰英,等.山楂叶抗大鼠PMN呼吸爆发谱效关系研究[J].中国中药杂志,2008,33(15):1884.
- [9]窦志华,罗琳,丁安伟,等.复方五仁醇胶囊含药血清指纹图谱与保肝作用的谱效关系[J].第四军医大学学报,2008,29(2):116.
- [10]卢红梅,梁逸曾,钱频.鱼腥草注射液质量控制中的谱效学初步探讨[J].药学学报,2005,40(2):1147.
- [11]孔维军,赵艳玲,山丽梅,等.左金丸及类方HPLC指纹图谱与生物热活性的“谱-效”关系研究[J].化学学报,2008,66(22):2533.
- [12]薛飞群,费陈忠,张丽芳,等.中药复方TF-103抗球虫活性与指纹图谱组效关系研究[J].中国兽药杂志,2006,40(3):1.
- [13]沈岚,张梁,冯怡,等.芍药甘草复方效应组分谱效关系研究[J].中国中药杂志,2008,33(22):2658.
- [14]陈晓燕,狄留庆,赵晓莉.中药复方谱效学研究初探[J].中国中医药信息杂志,2006,13(11):52.
- 陶金华
- 狄留庆
- 文红梅
- 赵晓莉
- 单进军
- 蔡宝昌
TAO Jinhua- DI Liuqing*
- WEN Hongmei
- ZHAO Xiaoli
- SHAN Jinjun
- CAI Baochang(Nanjing University of Chinese Medicine
- Nanjing 210046
- China)
- 陶金华
- 狄留庆
- 文红梅
- 赵晓莉
- 单进军
- 蔡宝昌
TAO Jinhua- DI Liuqing*
- WEN Hongmei
- ZHAO Xiaoli
- SHAN Jinjun
- CAI Baochang(Nanjing University of Chinese Medicine
- Nanjing 210046
- China)