中国中药杂志

2020, v.45(14) 3245-3250

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

基于系统中药学的中药功效标志物发现与应用
Discovery and application of traditional Chinese medicine efficacy markers based on systematic traditional Chinese medicine

霍梦琪;彭莎;任越;舒展;张燕玲;乔延江;
HUO Meng-qi;PENG Sha;REN Yue;SHU Zhan;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine, Research Center of Traditional Chinese Medicine-Information Engineering,Key Technology of Traditional Chinese Medicine Pharmacy and New Drug Development Engineering Research Center of Ministry of Education, School of Chinese Materia Medica, Beijing University of Chinese Medicine;

摘要(Abstract):

中药质量标志物是近年来提出的中药质量控制的新概念,是中药现代研究的热点问题。中药的功效是在中医药理论指导下对中药治疗作用的高度概括,在此基础上发掘中药的功效标志物对中药现代化发展具有重要意义。然而传统的基于中药宏观层面的单味药材和饮片研究,或者基于靶点生物学效应的药物研究策略与中药多种成分及对靶点的弱作用、低选择性的整体性作用特点存在较大差异,因此如何从分子层面选取代表性成分表征中药整体功效特点是建立中药功效标志物的研究难点。该研究将质量标志物的概念和方法引入中药功效研究中,以系统中药学的研究方法,以代表性的研究成果为例,论述了中药功效标志物的内涵及其发现和确定的原则、常用研究思路和方法,为中药功效标志物的研究和发现提供新的思路。
The quality marker(Q-marker) of traditional Chinese medicine(TCM) is a new concept of TCM quality control proposed in recent years. It is a hot issue in the research of modern Chinese medicine. The TCM efficacy is a high-level summary of the TCM therapeutic effect under the guidance of TCM theory. On this basis, it is of considerable significance to explore the TCM efficacy marker for the TCM modernization. However, the traditional research strategy based on the single herb and decoction piece in macro TCM level, or the drug research strategy based on the biological effect of the targets, is quite different from the characteristics of multiple components of TCM, as well as the weak and low-selective effect of Chinese medicine ingredients on targets. Therefore, how to select representative ingredients to characterize the TCM overall efficacy is a problematic point in establishing TCM efficacy markers. In this paper, the concept and method of Q-marker were introduced into the study of Chinese medicine efficacy. The research method for systematic TCM was used to systematically discuss the connotation of TCM efficacy markers, the principles of discovery and determination, common research ideas and techniques by taking the representative research results as an example. This study provides new ideas for the research and discovery of TCM efficacy markers.

关键词(KeyWords): 系统中药学;网络药理学;功效标志物;数据挖掘;中药质量控制
systematic traditional Chinese medicine;network pharmacology;efficacy marker;data mining;quality control of traditional Chinese medicine

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81573831,81430094)

作者(Author): 霍梦琪;彭莎;任越;舒展;张燕玲;乔延江;
HUO Meng-qi;PENG Sha;REN Yue;SHU Zhan;ZHANG Yan-ling;QIAO Yan-jiang;State Administration of Traditional Chinese Medicine, Research Center of Traditional Chinese Medicine-Information Engineering,Key Technology of Traditional Chinese Medicine Pharmacy and New Drug Development Engineering Research Center of Ministry of Education, School of Chinese Materia Medica, Beijing University of Chinese Medicine;

Email:

DOI:

参考文献(References):

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享