中国中药杂志

2007, (12) 1161-1164

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

白芍饮片HPLC指纹图谱的定量标示研究
Quantititive study for chromatographic fingerprints of processed products of Paeonia lactiflora

赫炎;赵慧东;唐力英;王祝举;张启伟;
HE Yan1,ZHAO hui-dong2,TANG Li-ying2,WANG Zhu-ju2,ZHANG Qi-wei2(1.Institute of Basic Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

摘要(Abstract):

目的:探讨如何应用HPLC指纹图谱的计量技术对白芍炒制过程及白芍饮片进行质量控制。方法:中试生产研制白芍饮片,HPLC,PFA(principal factor analysis)。结果:获得了较稳定的白芍饮片HPLC图谱;在不同产地和不同饮片品种图谱的10个特征峰中,通过各个峰之间的联带变化在不同饮片中的分布规律,运用PFA的信息处理技术,抽取出能反映对HPLC谱中峰群有影响的2个公共因子,其累计贡献率为64.8%,根据各峰对因子的载荷和communality筛选出的7个峰可作为主要反映图谱形状变化的目标峰群。结论:HPLC指纹图谱和PFA可用于白芍的炒制工艺过程和饮片的质量控制。
Objective:To explore the utility of Principal Factor Analysis(PFA) in chromatographic data for quality control.Method: Chromatographic fingerprints of processed root pieces of Paeonia lactiflora were determined by HPLC,the PFA was used for data processing.Result: The quantitative differences among different growing areas and different processing batches were found with the method.Conclusion: The method could be used in quality control for monitoring between-batch products of traditional Chinese pharmaceutical process.

关键词(KeyWords): 白芍;PFA;HPLC;色谱指纹图谱
Principal Factor Analysis;Paeonia lactiflora;chromatographic fingerprints

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 赫炎;赵慧东;唐力英;王祝举;张启伟;
HE Yan1,ZHAO hui-dong2,TANG Li-ying2,WANG Zhu-ju2,ZHANG Qi-wei2(1.Institute of Basic Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;2.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

Email:

DOI:

扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享