中国中药杂志

2017, v.42(01) 192-197

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中药浸膏粉的玻璃化转变及其应用
Glass transition of Chinese medicine extract powder and its application

罗晓健;刘慧;梁红波;熊磊;饶小勇;谢茵;何雁;
LUO Xiao-jian;LIU Hui;LIANG Hong-bo;XIONG Lei;RAO Xiao-yong;XIE Yin;HE Yan;Jiangxi University of Traditional Chinese Medicine;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine;Nanchang Hangkong University;Jiangxi Institute For Drug Control;

摘要(Abstract):

玻璃化转变理论是高分子科学中的一个重要理论,用于表征物理特性,是指无定形聚合物因受热从玻璃态到橡胶态或因冷却从橡胶态到玻璃态的转变。该文阐述了食品的玻璃态与玻璃化转变及中药浸膏粉成分与食品成分之间的相似关系,建立中药浸膏粉玻璃化转变温度(Tg)的测定方法,分析其主要影响因素。同时基于Tg对中药干燥工艺、制粒工艺与中药浸膏粉及其固体制剂储存中存在的问题进行分析与探讨并提出控制策略,以期为中药固体制剂的研发和生产提供指导意义。
Glass transition theory is an important theory in polymer science,which is used to characterize the physical properties. It refers to the transition of amorphous polymer from the glassy state to the rubber state due to heating or the transition from rubber state to glassy state due to cooling. In this paper,the glassy state and glass transition of food and the similar relationship between the composition of Chinese medicine extract powder and food ingredients were described; the determination method for glass transition temperature(Tg) of Chinese medicine extract powder was established and its main influencing factors were analyzed. Meanwhile,the problems in drying process,granulation process and Chinese medicine extract powder and solid preparation storage were analyzed and investigated based on Tg,and then the control strategy was put forward to provide guidance for the research and production of Chinese medicine solid preparation.

关键词(KeyWords): 中药浸膏粉;玻璃化转变;Tg;粘壁;粘轮;结块
Chinese medicine extract powder;glass transition;glass transition temperature;sticky wall;sticky wheel;caking

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81260644)

作者(Author): 罗晓健;刘慧;梁红波;熊磊;饶小勇;谢茵;何雁;
LUO Xiao-jian;LIU Hui;LIANG Hong-bo;XIONG Lei;RAO Xiao-yong;XIE Yin;HE Yan;Jiangxi University of Traditional Chinese Medicine;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine;Nanchang Hangkong University;Jiangxi Institute For Drug Control;

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DOI: 10.19540/j.cnki.cjcmm.20161222.043

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