中国中药杂志

2014, v.39(23) 4489-4493

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葛根芩连方中多成分肠渗透性的原药材归属研究
Study of attribution of multicomponent original medicinal materials in Gegen Qinlian decoction with intestinal permeability

朱美玲;杨文宁;董玲;董红环;侯成波;刘洋;
ZHU Mei-ling;YANG Wen-ning;DONG Ling;DONG Hong-huan;HOU Cheng-bo;LIU Yang;Beijing University of Chinese Medicine;

摘要(Abstract):

中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)构建的复杂层面为中药复方研究,在坚持多成分同时测定的前提下,开展渗透性研究时,其首要任务是明确透过肠壁而被吸收的成分来源,即具体归属于中药复方中的哪味药材。该研究利用化学成分指纹图谱技术(chemical fingerprint),采用离体翻转肠囊实验技术对经典名方葛根芩连方中的肠渗透多成分进行直观来源归属,为下一步的肠渗透性定性及定量研究奠定基础。
The complex level of constructing biopharmaceutics classification system of Chinese materia medica( CMMBCS) was the study of traditional Chinese compound,on the premise of insisting that the multicomponent simultaneous determination,when carrying out the study of intestinal permeability,the primary task was to define the source of the components that was absorbed through the intestinal wall,namely,which medicinal material the components belonged to in traditional Chinese compound. The technology of chemical fingerprint and in vitro everted gut sac model were used in this research to make multicomponent an intuitive source attribution which permeated the intestine in the classic formula Gegen Qinlian decoction,and to lay the foundation for the further qualitative and quantitative research of intestinal permeability.

关键词(KeyWords): 中药生物药剂学分类系统;葛根芩连方;渗透性;离体翻转肠囊;多成分;化学成分指纹图谱
biopharmaceutics classification system of Chinese materia medica;Gegen Qinlian decoction;permeability;in vitro everted gut sac;multicomponent;chemical fingerprint

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(81473362);; 北京中医药大学创新团队发展计划项目(2011-CXTD-13)

作者(Author): 朱美玲;杨文宁;董玲;董红环;侯成波;刘洋;
ZHU Mei-ling;YANG Wen-ning;DONG Ling;DONG Hong-huan;HOU Cheng-bo;LIU Yang;Beijing University of Chinese Medicine;

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