中国中药杂志

2014, v.39(16) 3010-3017

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代谢组学在中药现代研究的应用与展望
Perspective and application of metabonomics in modern study of traditional Chinese medicine

秦昆明;王彬;陈林伟;章茂森;杨光明;束雅春;蔡宝昌;
QIN Kun-ming;WANG Bin;CHEN Lin-wei;ZHANG Mao-sen;YANG Guang-ming;SHU Ya-chun;CAI Bao-chang;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine;Graduate Workstation Enterprises in Jiangsu Province,Nanjing Haichang Chinese Medicine Group Corporation;Affiliated Hospital of Nanjing University of Chinese Medicine;

摘要(Abstract):

代谢组学是研究机体代谢网络和代谢产物整体变化及内在变化规律的重要方法,与中药学的研究思路有一定的相似性。在中药现代化的研究过程中,充分借鉴代谢组学的研究方法,将加快传统中药学与现代生命科学的结合,推动中药现代化的发展。该文主要从代谢组学的概念、代谢组学在中药毒性作用机制、中药方剂配伍机制、中药方剂药效作用机制和中药炮制机制等研究中的应用予以阐述。总结了代谢组学在中药现代研究中存在的问题,并展望了发展前景。
Metabonomics is a new method to study on the metabolic network and the relationship between body and environment,which conforms to the way of traditional Chinese medicine( TCM) research. In the study process of modernization of traditional Chinese medicine,effectively conjunction with metabonomics method will facilitate the integration of TCM with modern biological science and technology,and promote the modernization of TCM. This paper introduce the application of metabonomics in the research of toxicity mechanism of TCM,compatibility mechanism of TCM formula,pharmacology effect of TCM and processing mechanism of TCM.This paper summarize the problems in the TCM metabonomics research and prospect its bright future.

关键词(KeyWords): 代谢组学;中药;机制
metabonomics;traditional Chinese medicine;mechanism

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基金项目(Foundation): 国家自然科学基金项目(81274056);; 江苏省自然科学基金项目(BK2011135);; 江苏省普通高校研究生创新工程计划项目(CXZZ13_0626);; 江苏省第九批“六大人才高峰”计划项目(WS-029)

作者(Author): 秦昆明;王彬;陈林伟;章茂森;杨光明;束雅春;蔡宝昌;
QIN Kun-ming;WANG Bin;CHEN Lin-wei;ZHANG Mao-sen;YANG Guang-ming;SHU Ya-chun;CAI Bao-chang;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine;Graduate Workstation Enterprises in Jiangsu Province,Nanjing Haichang Chinese Medicine Group Corporation;Affiliated Hospital of Nanjing University of Chinese Medicine;

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