中国中药杂志

2018, v.43(01) 39-45

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环烯醚萜苷类化合物体内代谢及代谢物药理活性研究进展
Research progress on metabolism and pharmacological activities of several iridoid glycosides

薛长松;徐晶;李萃萍;王宇;刘美辰;夏广清;
XUE Chang-song;XU Jing;LI Cui-ping;WANG Yu;LIU Mei-chen;XIA Guang-qing;Changbai Mountain Edible Plant Resource Development Engineering Center of Jilin Province,Tonghua Normal University;Key Lab of Changbai Mountain Plant Germplasm Resources Protection and Utilization Jilin Province,Tonghua Normal University;

摘要(Abstract):

环烯醚萜苷类化合物为一大类广泛存在于中药中的具有多种药理活性的天然产物。在生物转化作用下,环烯醚萜苷类化合物体内主要以原型、苷元及Ⅰ,Ⅱ相代谢产物形式存在,其代谢产物已被证实具有多种药理活性。该文综述常见的几种环烯醚萜类化合物体内代谢及代谢物活性的研究进展,为进一步合理开发利用环烯醚萜类成分及其代谢产物提供一定的理论依据。
As a large category of natural products widely present in traditional Chinese medicine,iridoid glycosides have multiple pharmacological activities.Recent researches suggest that iridoid glycosides mainly exist in vivo in the forms of original form,aglycone and a series of theirⅠ and Ⅱ metabolites under the biotransformation effect,and their metabolites have been proved to have multiple pharmacological activities.The research progress on in vivo metabolism and metabolite activities of several iridoid glycosides would be reviewed in this article,to provide a theoretical basis for the further development and utilization of iridoid compounds and their metabolites.

关键词(KeyWords): 环烯醚萜苷类化合物;代谢产物;药理活性
iridoid glycoside;metabolites;pharmacological activities

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基金项目(Foundation): 吉林省医药产业发展引导资金项目(20150311061YY);; 吉林省教育科学“十三五”规划(一般规划课题)(GH170568);; 通化师范学院高等教育教学改革研究项目

作者(Author): 薛长松;徐晶;李萃萍;王宇;刘美辰;夏广清;
XUE Chang-song;XU Jing;LI Cui-ping;WANG Yu;LIU Mei-chen;XIA Guang-qing;Changbai Mountain Edible Plant Resource Development Engineering Center of Jilin Province,Tonghua Normal University;Key Lab of Changbai Mountain Plant Germplasm Resources Protection and Utilization Jilin Province,Tonghua Normal University;

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