中国中药杂志

2022, v.47(10) 2676-2680

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2种唐松草属植物异喹啉类生物碱的研究
Isoquinoline alkaloids from two species of Thalictrum genus plants

薛晶晶;李建勇;李冰洁;金洋涛;王朝慧;薛春梅;张红梅;李占林;李达翃;华会明;
XUE Jing-jing;LI Jian-yong;LI Bing-jie;JIN Yang-tao;WANG Chao-hui;XUE Chun-mei;ZHANG Hong-mei;LI Zhan-lin;LI Da-hong;HUA Hui-ming;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University;

摘要(Abstract):

该文对2种唐松草属植物高原唐松草Thalictrum cultratum和贝加尔唐松草T.baicalense根的化学成分进行了研究。通过硅胶、氧化铝、ODS、Sephadex LH-20凝胶等多种柱色谱方法,以及制备高效液相等分离手段,从2种唐松草属植物乙醇提取物中分离鉴定了11个简单异喹啉类生物碱,包括1个新化合物,命名为去氢黄白蓬草碱(1),和10个已知化合物:N-甲基紫堇碱(2)、N-methylthalidaldine(3)、黄白蓬草碱(4)、氧化北美黄连次碱(5)、降氧化北美黄连次碱(6)、6,7-二甲氧基-2-甲基异喹诺酮(7)、thalactamine(8)、去氢降氧化北美黄连次碱(9)、6,7-二甲氧基-2-甲基-1,2,3,4-四氢异喹啉(10)、isopicnarrhine(11)。通过HR-ESI-MS、1D和2D NMR等波谱技术鉴定了化合物的结构。其中化合物1为新的简单异喹啉类生物碱,化合物11为首次从该属植物中分离得到。对化合物的细胞毒活性进行了评价,实验结果表明所有化合物对肿瘤细胞株HL-60、U937、HCT116、Caco-2、HepG2均无明显的细胞毒活性。
The chemical constituents from the roots of Thalictrum cultratum and T. baicalense were investigated. By various isolation methods, such as silica gel, aluminium oxide, ODS, and Sephadex LH-20 column chromatographies, and semi-preparative HPLC, 11 simple isoquinoline alkaloids were isolated from the ethanol extract of the roots of these two plants, including a new compound, named dehydrothalflavine(1), and ten known ones(2-11): N-methylcorydaline(2), N-methylthalidaldine(3), thaliflavine(4), oxyhydrastinine(5), noroxyhydrastinine(6), dimethoxyisoquinolone(7), thalactamine(8), dehydronoroxyhydrastinine(9), 6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline(10), and isopicnarrhine(11). Their structures were elucidated on the basis of HR-ESI-MS and 1 D and 2 D NMR techniques. Compound 1 was a new isoquinoline alkaloid. Compound 11 was obtained from Tha-lictrum plant for the first time. All compounds did not show cytotoxic activities against HL-60, U937, HCT116, Caco-2, and HepG2 cancer cell lines.

关键词(KeyWords): 高原唐松草;贝加尔唐松草;简单异喹啉类生物碱;细胞毒活性
Thalictrum cultratum;Thalictrum baicalense;simple isoquinoline alkaloid;cytotoxic activity

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(82173715);; 国家“重大新药创制”科技重大专项(2018ZX09735005);; 沈阳药科大学创新创业训练计划项目(202010163012)

作者(Authors): 薛晶晶;李建勇;李冰洁;金洋涛;王朝慧;薛春梅;张红梅;李占林;李达翃;华会明;
XUE Jing-jing;LI Jian-yong;LI Bing-jie;JIN Yang-tao;WANG Chao-hui;XUE Chun-mei;ZHANG Hong-mei;LI Zhan-lin;LI Da-hong;HUA Hui-ming;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University;

DOI: 10.19540/j.cnki.cjcmm.20211227.203

参考文献(References):

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