中国中药杂志

2014, v.39(15) 2851-2858

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治疗类风湿性关节炎常用药物的研究进展
Research progress of drugs commonly used to anti-rheumatoid arthritis

池里群;周彬;高文远;刘振;
CHI Li-qun;ZHOU Bin;GAO Wen-yuan;LIU Zhen;School of Pharmaceutical Science and Technology,Tianjin University;

摘要(Abstract):

类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性、进行性、多发性、侵袭性的,以关节滑膜炎和关节外病变为主要临床表现的自身免疫性疾病,好发于中年女性,儿童和老年人也有发病,具有渐进和反复发作的特点。RA发病机制复杂,尚无特效治疗,临床上用于治疗RA的药物多种多样,新药和新疗法也层出不穷,主要包括非甾体抗炎药、慢作用抗风湿药、糖皮质激素、生物制剂及中药与中药制剂。国内市场治疗RA的主要药物为非甾体抗炎药、慢作用抗风湿药、糖皮质激素和中药制剂。中药及中药制剂治疗RA有其独特的优势,表现出整体调节、多层次、多靶点的特点,而且还能缓解和对抗西药毒副作用,近年来越来越受到人们的重视。该文综述近年来治疗RA的常用药物的研究进展和治疗特色,为今后药物治疗RA提供参考和依据。
Rheumatoid arthritis(RA) is a kind of chronic,progressive,multiple,invasive autoimmune disease with two chief clinical manifestations arthrosynovitis and ex-arthrosis,easy to occur in middle-aged women,also occur in children and the elderly,is characterized by progressive and break out repeatedly.RA pathogenesis is complex,there is no special treatment,used in treatment of RA drug varied,new drugs and new therapies also emerge in endlessly,main including non-steroidal anti-inflammatory drugs(NSAIDs),slow action anti-rheumatism medicine(SAARDs),glucocorticoids(GCs),biological agent,traditional Chinese medicine and traditional Chinese medicine preparations,domestic market for rheumatoid main drug treatment are NSAIDs,SAARDs,GCs,traditional Chinese medicine and traditional Chinese medicine preparations.Traditional Chinese medicine and traditional Chinese medicine preparations for the treatment of RA have its unique advantages,show the characteristics of overall adjustment,multi-level and multiple targets,and also can alleviate and against side effects of western medicine.In recent years,more and more get people's attention.This paper reviewed the research progress and treatment features of commonly used therapeutic agents for the treatment of RA in recent years,which provides reference and basis for future medicine anti-RA.

关键词(KeyWords): 类风湿关节炎(RA);非甾体抗炎药;改善病情抗风湿药;中药
rheumatoid arthritis(RA);non-steroidal anti-inflammatory drugs;disease modifying anti-rheumatic drugs;traditional Chinese medicine

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作者(Author): 池里群;周彬;高文远;刘振;
CHI Li-qun;ZHOU Bin;GAO Wen-yuan;LIU Zhen;School of Pharmaceutical Science and Technology,Tianjin University;

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