中国中药杂志

2015, v.40(16) 3224-3228

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夏至草的黄酮类成分研究
Flavonoids from whole plants of Lagopsis supina

张静;庞道然;黄正;霍会霞;李月婷;郑姣;张倩;赵云芳;屠鹏飞;李军;
ZHANG Jing;PANG Dao-ran;HUANG Zheng;HUO Hui-xia;LI Yue-ting;ZHENG Jiao;ZHANG Qian;ZHAO Yun-fang;TU Peng-fei;LI Jun;Modern Research Center for Traditional Chinese Medicine,Beijing University of Chinese Medicine;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

摘要(Abstract):

研究夏至草Lagopsis supina全草的黄酮类化学成分。利用硅胶、Sephadex LH-20柱色谱和半制备HPLC等色谱方法分离纯化,结合其理化性质及MS、NMR等谱学数据鉴定化合物的结构。从夏至草提取物二氯甲烷萃取部位分离得到2个黄酮苷元,分别鉴定为芫花素(1)、5-羟基-7,4'-二甲氧基黄酮(2)。从夏至草提取物水部位分离得到10个黄酮苷类化合物,分别鉴定为山柰酚-3-O-6″-(3-羟基-3-甲基-戊二酸单酰基)-β-D-葡萄糖苷(3)、槲皮素-3-O-6″-(3-羟基-3-甲基-戊二酸单酰基)-β-D-葡萄糖苷(4)、槲皮素-3-O-β-D-葡萄糖苷(5)、山柰酚-3-O-β-D-葡萄糖苷(6)、异鼠李素-3-O-β-D-葡萄糖苷(7)、芹菜素-7-O-β-D-葡萄糖苷(8)、木犀草素-7-O-β-D-葡萄糖苷(9)、柯伊利素-7-O-β-D-葡萄糖苷(10)、芦丁(11)、山柰酚-3-O-(6″-对-香豆酰基)-β-D-葡萄糖苷(银椴苷,12)。化合物3和4为首次从唇形科植物中分离得到,化合物1~12均为首次从夏至草属植物中分离得到。
The flavonoids were investigated from the whole plants of Lagopsis supina. The compounds were isolated and purified by various column chromatography,and their structures were identified by physiochemical properties and spectroscopic data. Two flavones were isolated from the CH2Cl2 layer of Lagopsis supina extract and identified as genkwanin( 1) and 5-hydroxy-7,4'-dimethoxyflavone( 2),respectively. Ten flavonoid glycosides were isolated from the water layer of Lagopsis supina and elucidated as kaempferol-3-O-6″-( 3-hydroxy-3-methylglutaryl)-β-D-glucoside( 3),quercetin-3-O-6″-( 3-hydroxy-3-methylglutaryl)-β-D-glucoside( 4),quercetin-3-O-β-D-glucoside( 5),kaempferol-3-O-β-D-glucoside( 6),isorhamnetin-3-O-β-D-glycopyranoside( 7),apigenin-7-O-β-D-glucoside( 8),luteolin-7-O-β-D-glucoside( 9),chrysoeriol-7-O-β-D-glucoside( 10),rutin( 11),and kaempferol-3-O-( 6″-p-coumaroyl)-β-D-glucoside( tiliroside,12). Compounds 3 and 4 were firstly isolated from Lamiaceae family,and compounds 1-12 were isolated from the plants of Lagopsis genus for the first time.

关键词(KeyWords): 夏至草属;夏至草;化学成分;黄酮;黄酮苷
Lagopsis;Lagopsis supina;chemical constituent;flavone;flavonoid glycoside

Abstract:

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基金项目(Foundation): 教育部新世纪优秀人才支持计划项目(NCET-13-0693);; 国家“重大新药创制”科技重大专项(2013ZX09402201001)

作者(Author): 张静;庞道然;黄正;霍会霞;李月婷;郑姣;张倩;赵云芳;屠鹏飞;李军;
ZHANG Jing;PANG Dao-ran;HUANG Zheng;HUO Hui-xia;LI Yue-ting;ZHENG Jiao;ZHANG Qian;ZHAO Yun-fang;TU Peng-fei;LI Jun;Modern Research Center for Traditional Chinese Medicine,Beijing University of Chinese Medicine;School of Chinese Materia Medica,Beijing University of Chinese Medicine;

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