中国中药杂志

2016, v.41(17) 3252-3255

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中药何首乌的化学成分研究
Chemical constituents from Polygonum multiflorum

张静娴;崔艳梅;
ZHANG Jing-xian;CUI Yan-mei;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Ministry of Education & Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College;

摘要(Abstract):

中药何首乌乙酸乙酯部位经硅胶柱色谱、ODS反相柱色谱、Sephadex LH-20凝胶过滤和高效液相制备等方法进行分离纯化,通过1D-NMR,2D-NMR和HR-ESI-MS等波谱学方法鉴定分得化合物的结构,共分离并鉴定了6个化合物,分别为2,3,5,4'-四羟基二苯乙烯-2-O-(2″-O-对羟基苯甲酰基)-β-D-葡萄糖苷(1),2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(2),2,4,6,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷(3),大黄素-8-O-β-D-葡萄糖苷(4),大黄素甲醚-8-O-β-D-葡萄糖苷(5),大黄素-8-甲醚(6)。其中化合物1为新化合物。
Six compounds were isolated from the ethyl acetate extract of the tuberous root of Polygonum multiflorum by silical gel,ODS revsered-phase silica gel,Sephadex LH-20,and preparative HPLC. The structures were elucidated as column chromatography over: 2,3,5,4'-tetrahydroxystilbene-2-O-( 2″-O-p-hydroxybenzoyl)-β-D-glucoside( 1),2,3,5,4'-tetrahydroxystilbene-2-O-β-Dglucoside( 2),2,4,6,4'-tetrahydroxystilbene-2-O-β-D-glucoside( 3),emodin-8-O-β-D-glucopyranoside( 4),physcion-8-O-β-D-glucopyranoside( 5),and 8-O-methyl-emodin( 6) on the basis of spectral analysis. Compound 1 is a new stilbene glycoside.

关键词(KeyWords): 何首乌;化学成分;2,3,5,4'-四羟基二苯乙烯-2-O-(2″-O-对羟基苯甲酰基)-β-D-葡萄糖苷
Polygonum multiflorum;chemical constituents;2,3,5,4'-tetrahydroxystilbene-2-O-(2″-O-p-hydroxybenzoyl)-β-D-glucoside

Abstract:

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基金项目(Foundation): 国家“重大新药创制”科技重大专项(2012ZX09301002001003)

作者(Author): 张静娴;崔艳梅;
ZHANG Jing-xian;CUI Yan-mei;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Ministry of Education & Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College;

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