中国中药杂志

2014, v.39(17) 3321-3325

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7种海洋矿物药的比较分析研究
Comparative analysis of seven marine biological source of mineral drugs

司玮;阿如娜;李尚蓉;张静娴;吴婉莹;崔亚君;
SI Wei;A Ru-na;LI Shang-rong;ZHANG Jing-xian;WU Wan-ying;CUI Ya-jun;Shanghai University of Traditional Chinese Medicine College of Traditional Chinese medicine;National Engineering Laboratory for ,TCM Standardization Technology,Shanghai Research Center for Modernization of Traditional Chinese Medicine,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;

摘要(Abstract):

《中国药典》2010年版收载的海洋矿物药主要包括珍珠、珍珠母、蛤壳、牡蛎、瓦楞子、海螵蛸、石决明等,该类药材化学成分组成相似,主要是碳酸钙和少量的蛋白质。该文采用EDTA络合滴定法测定碳酸钙的含量;采用X射线粉末衍射,测定其碳酸钙晶型;采用紫外分光光度法对水解后样品中总氨基酸进行测定。通过系统的比较研究,寻找该类药材的差异性,结果显示,所收集的样品中牡蛎所含碳酸钙为三方晶系方解石,石决明及珍珠母晶型为三方晶系方解石与斜方晶系文石混合晶型,其余4种均为斜方晶系文石;所有样品的碳酸钙质量分数在86%~96%;海螵蛸中总氨基酸质量分数最高达1.70%、蛤壳中最低,平均为0.16%。通过对7种海洋矿物药中碳酸钙和总氨基酸的分析,建立了一种对海洋矿物药质量控制的有效方法。
The marine biological source of mineral drugs recorded in Chinese Pharmacopoeia(2010 version) mainly including pearl,nacre,clam shell,common oyster shell,ark shell,cuttle bone,and sea-ear shell are widely used in clinical.Calcium carbonate and a small amount of protein are the main components in this type of drugs.In this paper,a systematical and comparable study were carried out by determination of calcium carbonate by EDTA titration method,the crystal of calcium carbonate by X-Ray powder diffraction and the total amino acids(TAAs) of the hydrolyzed samples by ultraviolet spectrophotometry method.As a result,the crystal structure is calcite for common oyster shell,mixture of calcite and aragonite for nacre and sea-ear shell,aragonite for the other drugs.The content of calcium carbonate ranged from 86% to 96% .Cuttle bone has the highest amount of TAAs among the seven drugs which reached 1.7% while clam shell has the lowest content of 0.16% on average.In conclusion,an effective method was developed for the quality control of marine mineral drugs by comprehensive analysis of calcium carbonate and TAAs in the seven marine mineral drugs.

关键词(KeyWords): 海洋矿物药;x射线衍射;碳酸钙;氨基酸;EDTA络合滴定;紫外分光光度法
marine biological source of mineral drugs;X-ray powder diffraction;calcium carbonate;total amino acids;EDTA titration method;ultraviolot spectrophotometry method

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基金项目(Foundation): 国家高技术研究发展计划(863)项目(2013AA093002);; 2015年版药典标准提高项目

作者(Author): 司玮;阿如娜;李尚蓉;张静娴;吴婉莹;崔亚君;
SI Wei;A Ru-na;LI Shang-rong;ZHANG Jing-xian;WU Wan-ying;CUI Ya-jun;Shanghai University of Traditional Chinese Medicine College of Traditional Chinese medicine;National Engineering Laboratory for ,TCM Standardization Technology,Shanghai Research Center for Modernization of Traditional Chinese Medicine,Shanghai Institute of Materia Medica,Chinese Academy of Sciences;

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