中国中药杂志

2020, v.45(12) 2772-2783

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香加皮的化学成分与药理作用研究进展及质量标志物的预测分析
Research progress on chemical composition and pharmacological effects of Periplocae Cortex and predictive analysis on Q-marker

杨雪;李梦雨;颜昌钖;肖治均;蒋维奇;王小雨;崔曦兮;李文鲜;姚柯男;刘传鑫;
YANG Xue;LI Meng-yu;YAN Chang-yang;XIAO Zhi-jun;JIANG Wei-qi;WANG Xiao-yu;CUI Xi-xi;LI Wen-xian;YAO Ke-nan;LIU Chuan-xin;Department of Pharmacy, Changzhi Medical College;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

摘要(Abstract):

香加皮为我国传统中药,主产于我国东北、华北、西北和西南等地。近年来随着研究深入,香加皮的抗肿瘤和强心等药理活性被发现,具有广泛的应用前景。该文基于香加皮化学成分和药理作用的研究,结合质量标志物(Q-marker)的理论体系,从香加皮的化学成分与亲缘关系、传统功效性味、新的药效用途相关性、可测成分、入血成分和贮藏时间方面,通过文献分析论证对香加皮质量标志物进行预测,其中杠柳苷、杠柳毒苷、杠柳苷元、4-甲氧基水杨醛活跃程度较强,可为香加皮质量评价提供一定的科学依据。
Periplocae Cortex is a traditional Chinese medicine in China, which is mainly produced in northeast China, north China, northwest China, southwest China. In recent years, the increasing in-depth research resulted in the discovery of anti-tumor and cardiac pharmacological activities of Periplocae Cortex, which has broad application prospects. On the basis of summarizing chemical components and pharmacological effects, combined with the theoretical system of Q-marker, the quality control components of Periplocae Cortex were predicted from the aspects of the correlation between chemical composition and traditional medicinal properties, traditional efficacy, and new clinical use, plasma composition, measurable composition, storage time by analyzing literature. Among the components, periplocoside, periplocin, periplogenin, 4-methoxy salicylaldehyde showed significant activity, which provides a scientific basis for quality evaluation of Periplocae Cortex.

关键词(KeyWords): 香加皮;强心苷类;杠柳毒苷;质量标志物;质量评价
Periplocae Cortex;cardiac glycosides;periplocin;quality marker(Q-marker);quality evaluation

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作者(Author): 杨雪;李梦雨;颜昌钖;肖治均;蒋维奇;王小雨;崔曦兮;李文鲜;姚柯男;刘传鑫;
YANG Xue;LI Meng-yu;YAN Chang-yang;XIAO Zhi-jun;JIANG Wei-qi;WANG Xiao-yu;CUI Xi-xi;LI Wen-xian;YAO Ke-nan;LIU Chuan-xin;Department of Pharmacy, Changzhi Medical College;School of Chinese Materia Medica, Beijing University of Chinese Medicine;

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