中国中药杂志

2015, v.40(12) 2285-2288

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黄连抗氧化作用与糖尿病的研究进展
Progress in study of antioxidant effects of Coptis chinensis and its major contributions to diabetes treatment / therapy

张倩;梁晓春;
ZHANG Qian;LIANG Xiao-chun;Department of Traditional Chinese Medicine,Peking Union Medical College Hospital;

摘要(Abstract):

黄连为我国传统中药,现代研究发现黄连具有多种药理作用。黄连具有抗氧化作用,可能通过清除氧自由基、减轻脂质过氧化反应、增强抗氧化酶活性等途径对抗高糖诱导的氧化应激损伤,同时可以抑制糖尿病多个经典病理途径的损伤,对于防治糖尿病及慢性并发症具有良好的应用前景。该文对黄连及其主要成分的抗氧化作用与糖尿病的相关研究进展进行综述。
Coptis chinensis,a traditional Chinese medicine,has been found to have multiple pharmacological effects recently. Some research showed that C. chinensis has antioxidant effects,including scavenging oxygen free radicals,alleviating lipid peroxidation,enhancing activity of antioxidant enzymes,et al. C. chinensis may inhibit several classical pathological pathways in diabetes. C. chinensis is a potential medicine to prevent and treat diabetes mellitus and its complications. This review focuses on the recent research progress in the study of antioxidant effects of C. chinensis and its major contributions to diabetes treatment / therapy.

关键词(KeyWords): 黄连;黄连素;抗氧化;氧化应激;糖尿病
Coptis chinensis;berberine;antioxidant;oxidative stress;diabetes

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作者(Author): 张倩;梁晓春;
ZHANG Qian;LIANG Xiao-chun;Department of Traditional Chinese Medicine,Peking Union Medical College Hospital;

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