中国中药杂志

2004, (07)

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4种川芎化学成分与心肌细胞膜受体作用的研究
Study on the interactions between four components in Ligusticum chuanxiong rhizome and acceptors on cardiac muscle membrane

张延妮,岳宣峰,张志琪
ZHANG Yan-ni, YUE Xuan-feng , ZHANG Zhi-qi (Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education, Shaanxi Normal University, Xi'an 710062, China)

摘要(Abstract):

目的 :研究川芎化学成分与心肌细胞膜受体的作用。方法 :通过 4种川芎化学成分 (川芎嗪、香兰素、大黄酚和阿魏酸 )在心肌细胞膜固定相色谱柱上的保留特性 ,研究其与心肌细胞膜受体的作用 ;进一步将这些保留特性与心肌细胞膜上已知受体拮抗剂和激动剂的色谱保留特性比较以研究作用的受体类型。结果 :川芎嗪、香兰素、大黄酚在心肌细胞膜固定相色谱柱上有保留特性 ,阿魏酸无保留 ;川芎嗪的保留特性与α受体拮抗剂和α受体激动剂相近 ,香兰素的保留特性与 β1受体激动剂相近。结论 :川芎嗪、香兰素、大黄酚均可作用于心肌细胞膜受体 ,阿魏酸不与心肌细胞膜上的受体作用 ;川芎嗪有可能作用于α受体 ,香兰素有可能作用于 β1受体。
Objective: To study the interactions between four components in Ligusticum chuanxiong rhizome and heart cell membrane acceptors. Method: Through observing the retention characteristics of the four components (tetramethylpyrazine, vanillic, chrysophol, ferulic acid) on cell membrane stationary phase (CMSP) chromatographic column, whether the components combine with cell membrane acceptors was studied, and through further comparing the retention characteristics with those of known activators or antagonists corresponding to cell membrane acceptors, the kind of acceptor with which one component combines was studied. Result:Tetramethylpyrazine, vanillic and chrysophol had retention on CMSP chromatographic column while ferulic acid hadn't. The retention characteristics of tetramethylpyrazine were similar to activator and antagonist corresponding to α acceptor, vanillic with β 1 acceptor activator. Conclusion: Tetramethylpyrazine, vanillic and chrysophol can all combine with cardiac muscle membrane acceptors, while ferulic acid can not; tetramethylpyrazine probably acts on α acceptor and vanillic acts on β 1 acceptor.

关键词(KeyWords): 川芎;化学成分;心肌细胞膜受体;细胞膜色谱
Ligusticum chuanxiong; chemical components; cardiac muscle membrane acceptor; cell membrane chromatography

Abstract:

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基金项目(Foundation): 国家自然科学基金资助项目 ( 2 0 175 0 12 );; 教育部科技重点项目 ( 0 115 6)

作者(Author): 张延妮,岳宣峰,张志琪
ZHANG Yan-ni, YUE Xuan-feng , ZHANG Zhi-qi (Key Laboratory of Medicinal Plant Resource and Natural Pharmaceutical Chemistry of Ministry of Education, Shaanxi Normal University, Xi'an 710062, China)

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