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山麦冬水溶性提取物对麻醉猫血液动力学的影响
Hemodynamic Effects of Water Soluble Extract of Liriope spicata Lour on Anesthetized Cats

高广猷,李传勋,段鹏,韩晓燕,杨月琴
Gao Guangyou, Li Chuanxun, Duan Pong, Han Xiaoyan Yang Yueqin(Department of Pharmacology, Dalian Medical Colloge)

摘要(Abstract):

给麻醉猫静脉注射山麦冬水溶性提取物1.75g/kg,其LV dp/dt max增加86%,t-dp/dtmax缩短28%。CO,CI,SI,和LVWI分别增加146%,151%,150%和194%。心率轻度减慢,SVR降低48%。本品0.7g/kg,iv,LV dp/dt max增加38%,CO增加44%,t-dp/dt max缩短20%,SVR降低20%。结果提示,本品有正性肌力作用,并能改善心脏泵功能。
The effects of water soluble extract of Liriope spicata on acute hemodynamics were studied in anesthetized cats. The results showed that LV dp/dt max was increased by 87%, whereas tdp/dt max was shortened by 28% after administration of WSEL (1.75g/kg, ⅳ). At the same time CO, CI, SI, and SVWI were increased by 146, 151, 153, and 194%, respectively, HR was declined slightly. SVR was reduced by about 48%. WSEL (0.79/kg, ⅳ) induced an increase of 38% in LV dp/dt max, 44% in CO, 50% in SI and a decrease of 20% in t-dp/dt max and 20% in SVR. Preliminary results indicated that WSEL increased ventricular contractile force and might increase cardiac pump function.

关键词(KeyWords): 山麦冬水溶性提取物;血液动力学参数;心脏泵功能
water soludle extract of Liriopc spicata; hemodynamic parameter; cardiac pump function

Abstract:

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作者(Author): 高广猷,李传勋,段鹏,韩晓燕,杨月琴
Gao Guangyou, Li Chuanxun, Duan Pong, Han Xiaoyan Yang Yueqin(Department of Pharmacology, Dalian Medical Colloge)

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