高广猷,李传勋,段鹏,韩晓燕,杨月琴
Gao Guangyou, Li Chuanxun, Duan Pong, Han Xiaoyan Yang Yueqin(Department of Pharmacology, Dalian Medical Colloge)

• 1:大连医学院药理教研室
• 2:大连医学院药理教研室
• 3:山西汾阳高级护校药理教研室
• 4:大连医学院药理教研室

摘要(Abstract)：

给麻醉猫静脉注射山麦冬水溶性提取物1.75g/kg,其LV dp/dt max增加86%,t-dp/dtmax缩短28%。CO,CI,SI,和LVWI分别增加146%,151%,150%和194%。心率轻度减慢,SVR降低48%。本品0.7g/kg,iv,LV dp/dt max增加38%,CO增加44%,t-dp/dt max缩短20%,SVR降低20%。结果提示,本品有正性肌力作用,并能改善心脏泵功能。
The effects of water soluble extract of Liriope spicata on acute hemodynamics were studied in anesthetized cats. The results showed that LV dp/dt max was increased by 87%, whereas tdp/dt max was shortened by 28% after administration of WSEL (1.75g/kg, ⅳ). At the same time CO, CI, SI, and SVWI were increased by 146, 151, 153, and 194%, respectively, HR was declined slightly. SVR was reduced by about 48%. WSEL (0.79/kg, ⅳ) induced an increase of 38% in LV dp/dt max, 44% in CO, 50% in SI and a decrease of 20% in t-dp/dt max and 20% in SVR. Preliminary results indicated that WSEL increased ventricular contractile force and might increase cardiac pump function.

关键词(KeyWords)： 山麦冬水溶性提取物;血液动力学参数;心脏泵功能
water soludle extract of Liriopc spicata; hemodynamic parameter; cardiac pump function

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 高广猷,李传勋,段鹏,韩晓燕,杨月琴
Gao Guangyou, Li Chuanxun, Duan Pong, Han Xiaoyan Yang Yueqin(Department of Pharmacology, Dalian Medical Colloge)

参考文献(References)：

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• [3] 高广猷等.大连医学院学报 1986;8(3) :30
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• [6] 高广猷等.大连医学院学报 1984;6(3) :12