中国中药杂志

2007, (11) 1054-1056

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牡丹皮饮片指纹图谱的聚类分析
Clustering analysis of HPLC chromatographic fingerprints of Paeonia suffruticosa

吴美珍;赫炎;唐力英;王祝举;
WU Mei-zhen~1 HE Yan~3 TANG Li-ying~2 WANG Zhu-ju~2 1.Sir Sun Sun Shaw Hospital,Medical College of Zhejiang University,Hangzhou 310016,China; 2.Institute of Basic Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

摘要(Abstract):

目的:探讨如何应用HPLC指纹图谱对牡丹皮饮片进行质量控制。方法:中试生产研制牡丹皮饮片, HPLC。结果:获得了较稳定的HPLC图谱;在不同产地和不同饮片13个样品的图谱的13峰中,通过其峰面积的变化的分布规律。计算各样品的相似程度,运用聚类分析,对样品产地和加工对其HPLC图谱的相关性进行了分析,分类结果同材产地一致,同加工无关。结论:就检测HPLC指纹图谱所反映的药用物质基础而言牡丹皮的加工处理对其影响不显著,产地起主要因素。提示产地为饮片质量控制的重要因素。
Objective:To explore the utility of chromatographic data for quality control of Paeonia suffruticosa,a Chinese herbal medicine.Method:Chromatographic fingerprints of Paeonia suffruticosa,were determined by HPLC,the clustering analysis was used for data processing.Result:The quantitative differences among different growing awes were found and could be used to clas- sify herbals from different growing areas,while there seemed to be no quantitative differences for processing factor.Conclusion:The method could be used in quality control for monitoring herbal quality control,and the result also suggested that different growing areas may greatly affected the herbal qualities.

关键词(KeyWords): 牡丹皮;HPLC;指纹图谱;质量控制
clustering analysis;Paeonia suffruticosa;chromatographic fingerprints

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作者(Author): 吴美珍;赫炎;唐力英;王祝举;
WU Mei-zhen~1 HE Yan~3 TANG Li-ying~2 WANG Zhu-ju~2 1.Sir Sun Sun Shaw Hospital,Medical College of Zhejiang University,Hangzhou 310016,China; 2.Institute of Basic Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China; 3.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

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