中国中药杂志

2005, (06) 410-414

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香豆素类化合物生物学活性研究进展
Advances on biological activities of coumarins

张韶瑜,孟林,高文远,宋乃宁,贾伟,段宏泉
ZHANG Shao-yu~1, MENG Lin~1, GAO Wen-yuan~2, SONG Nai-ning~1, JIA Wei~3, DUAN Hong-quan~1(1. Tianjin Medical University, Tianjin 300070, China; 2. The College of Pharmaceutical and Biotechnology, Tianjin University, Tianjin 300072, China; 3. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200030, China )

摘要(Abstract):

综述了近10年来香豆素类化合物有效成分及生物学活性的研究进展。香豆素是自然界很重要的一大类天然有机化合物,实验研究发现香豆素类化合物具有抗HIV、抗癌、降压、抗心律失常、抗骨质疏松、镇痛、平喘及抗菌等多方面生物学活性。因此,完善香豆素类化合物提取分离工艺,寻找有效的先导化合物,合成并筛选出高效低毒的香豆素类衍生物已成为药物研发工作的重要方向之一。
This paper reviewed the advances on effective constituents and biological activities of coumarins in recent ten years. Coumarins are a group of important natural compounds, and have been found to have multi-biological activities such as anti-HIV, anti-tumor, anti-hypertension, anti-arrhythmia, anti-osteoporosis, assuaging pain, preventing asthma and antisepsis. Therefore, further investigation should emphasize on improving techniques for extraction and separation, searching the effective precursory compound, and synthesizing and screening out courmarin derivatives with high activity and low toxicity.

关键词(KeyWords): 香豆素;生物学活性;有效成分
coumarin; biological activity; effective constituent

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作者(Author): 张韶瑜,孟林,高文远,宋乃宁,贾伟,段宏泉
ZHANG Shao-yu~1, MENG Lin~1, GAO Wen-yuan~2, SONG Nai-ning~1, JIA Wei~3, DUAN Hong-quan~1(1. Tianjin Medical University, Tianjin 300070, China; 2. The College of Pharmaceutical and Biotechnology, Tianjin University, Tianjin 300072, China; 3. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200030, China )

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