通光藤的化学成分研究Studies on the chemical constituents in stem of Marsdenia tenacissima
邢旺兴,陈斌,宓鹤鸣,杨根金,吴玉田
XING Wang xing 1, CHEN Bin 2, MI He ming 2, YANG Gen jin 2, WU Yu tian 2 (1.Department of Pharmaceutical Preparations, 117th Hospital of Chinese People Liberation Army, Hangzhou 310013, China; 2.School of Pharmacy, Second Military Medical University, Shanghai 200433, China)
摘要(Abstract):
目的 :研究中药通光藤Marsdeniatenacissima的化学成分。方法 :利用溶剂提取和硅胶、SephadexLH 2 0等色谱方法对云南昆明产通光藤的醋酸乙酯可溶部位进行分离纯化 ,通过化学和光谱方法鉴定结构。结果 :共分离得到 8个化合物 ,已鉴定出其中 5个化合物 :大叶牛奶菜苷丁 (Ⅰ ) ,大叶牛奶菜苷乙 (Ⅱ ) ,牛奶菜醇 (Ⅲ ) ,二氢牛奶菜醇 (Ⅳ ) ,喙柱牛奶菜苷乙 (Ⅴ )。结论 :这 5个化合物均为首次从该植物中分离得到 ;通光藤的醋酸乙酯可溶部位含有较多的甾体酯苷类化合物。
Objective: To study on the chemical constituents of Marsdenia tenacissima. Method: Compounds were separated with chromatography technology with sillica gel and Sephadex LH 20 as adsorbents, and their structures were elucidated by chemical and spectral analysis. Result: Eight compounds were isolated from Marsdenia tenacissima and the structures of five compounds among them were identified as marsdekoiside D(Ⅰ), marsdekoiside B(Ⅱ), conduritol (Ⅲ), dihydro conduritol (Ⅳ) and marsdeoreophiside B(Ⅴ). Conclusion: All these compounds were obtained from this genus for the first time.
关键词(KeyWords):
通光藤;大叶牛奶菜苷;牛奶菜醇;喙柱牛奶菜苷
Marsdenia tenacissima; marsdekoiside; conduritol; marsdeoreophiside
基金项目(Foundation): 全军医学科研重点课题基金 (0 1Z0 64 )
作者(Author):
邢旺兴,陈斌,宓鹤鸣,杨根金,吴玉田
XING Wang xing 1, CHEN Bin 2, MI He ming 2, YANG Gen jin 2, WU Yu tian 2 (1.Department of Pharmaceutical Preparations, 117th Hospital of Chinese People Liberation Army, Hangzhou 310013, China; 2.School of Pharmacy, Second Military Medical University, Shanghai 200433, China)
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DOI:
参考文献(References):
- [1] 邢旺兴.中药通光藤活性成分的研究:[第二军医大学博士学位论文].上海:第二军医大学,2002.
- [2] 孙 珏,沈建华,朱美华,等.消癌平对人胃癌细胞治疗作用的实验研究.上海中医药大学学报,2000,14(2):41.
- [3] 孙 珏,沈建华,朱美华,等.中药消癌平针剂经肝动脉介入治疗转移性肝癌的临床研究.上海中医药杂志,2000,34(1):14.
- [4] 蒋 毅,罗思齐.通关藤中新C21甾体甙的化学结构研究.中国医药工业杂志,1996,27(9):391.
- [5] 木全章.植物C21甾体化合物成分提取分离和结构鉴定.见:香港科技大学生物技术研究所.中药研究与开发综述.北京:科学出版社,2000.223.
- [6] 陈纪军,张壮鑫,周 俊.通光藤甙F ,G ,H和I结构.云南植物研究,1999,21(3):369.
- [7] 阮金兰,丁惟培,吕植桢,等.大叶牛奶菜抗生育成分的研究.同济医科大学学报,1991,20(2):81.
- [8] 阮金兰,徐小前,陈桂先,等.大叶牛奶菜化学成分的研究(Ⅴ).中草药,1992,23(1):6.
- [9] 于德泉,杨峻山.分析化学手册.第七分册·核磁共振波谱分册.第二版.北京:化学工业出版社,1999.804.
- [10] 张玉娥,阮金兰,丁惟培.喙柱牛奶菜抗生育成分的研究.药学学报,1994,29(4):281.
- 邢旺兴
- 陈斌
- 宓鹤鸣
- 杨根金
- 吴玉田
XING Wang xing 1 - CHEN Bin 2
- MI He ming 2
- YANG Gen jin 2
- WU Yu tian 2 (1.Department of Pharmaceutical Preparations
- 117th Hospital of Chinese People Liberation Army
- Hangzhou 310013
- China
- 2.School of Pharmacy
- Second Military Medical University
- Shanghai 200433
- China)
- 邢旺兴
- 陈斌
- 宓鹤鸣
- 杨根金
- 吴玉田
XING Wang xing 1 - CHEN Bin 2
- MI He ming 2
- YANG Gen jin 2
- WU Yu tian 2 (1.Department of Pharmaceutical Preparations
- 117th Hospital of Chinese People Liberation Army
- Hangzhou 310013
- China
- 2.School of Pharmacy
- Second Military Medical University
- Shanghai 200433
- China)