中国中药杂志

2019, v.44(15) 3195-3202

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中药干法制粒的研究思路探讨:基于干法制粒技术研究的国内外研究进展
Discussion on research thought of dry granulation of traditional Chinese medicine: research progress at home and abroad based on dry granulation technology

况弯弯;伍振峰;万娜;李远辉;王学成;康超超;刘振峰;杨明;
KUANG Wan-wan;WU Zhen-feng;WAN Na;LI Yuan-hui;WANG Xue-cheng;KANG Chao-chao;LIU Zhen-feng;YANG Ming;State Key Laboratory of Innovation Drug and Efficient Energy-saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine;Yichun Wanshen Pharmaceutical Machinery Co.,Ltd.;

摘要(Abstract):

干法制粒技术是制粒技术上一大创新,省去了很多中间环节,降低了很多中间费用,其与物料的特性、干法制粒设备与工艺等密切相关。干法制粒技术是覆盖多个技术领域的一门系统工程科学,干法制粒过程涉及复杂的温度场、压力场、速度场数学模型机制,又与物料的特性、干燥设备等密切相关。但由于中药干法制粒技术研究起步较晚,基础研究仍较薄弱。而干法制粒技术研究在食品、化工、农林等领域取得了很大的成果,具有重要的借鉴意义。中药干法制粒的优点是中药浸膏粉中添加适量辅料后,可直接制粒,无需湿润、混合、干燥等过程,工艺简便,能有效保证中药质量。采用干法制粒技术获得的颗粒是制备中药固体制剂的重要中间体,直接影响后续其他制剂成型工艺与制剂产品质量。因此,立足于中药干法制粒自身的特性,通过借鉴其他领域干法制粒技术先进的研究成果,围绕干法制粒设备、工艺、在线检测技术、干法制粒过程数学模型机理研究,探讨中药干法制粒的研究思路,以期为中药干法制粒的研究提供参考。
Dry granulation technology is a great innovation in granulation technology,which saves many intermediate links and reduces many intermediate costs. It is closely related to the characteristics of materials,dry granulation equipment and process. Dry granulation technology is a systematic engineering science covering many technical fields. The process of dry granulation involves complex mathematical model mechanisms of temperature field,pressure field and velocity field,closely related to the characteristics of materials and drying equipment. However,due to the late start of research on dry granulation technology of traditional Chinese medicine,basic research is still weak. The research on dry granulation technology has achieved great results in the fields of food,chemical industry,agriculture and forestry,showing great reference significance. The advantage of dry granulation of traditional Chinese medicine is that it can be directly granulated by adding an appropriate amount of auxiliary materials in the extract powder of traditional Chinese medicine,without the need of wetting,mixing,drying and other processes. The process is simple and can effectively guarantee the quality of traditional Chinese medicine. The granules obtained by the dry granulation technique are important intermediates for preparing the solid preparations of traditional Chinese medicines,which would directly affect the subsequent molding process and the quality of the preparation products. Therefore,based on the characteristics of dry granulation method in traditional Chinese medicine and by referring to the advanced research results of dry granulation technology in other fields,we would discuss the research ideas of dry granulation in traditional Chinese medicine in terms of the mechanism of dry granulation equipment,technology,on-line detection technology and mathematical model of dry granulation process,hoping to provide reference for the research of dry granulation method in traditional Chinese medicine.

关键词(KeyWords): 中药;干法制粒技术;在线检测与预测模型;质量评价;研究思路
Chinese medicine;dry granulation technology;on-line detection and prediction model;quality evaluation;research ideas

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基金项目(Foundation): 江西省5511重大专项(20182ABC28009);; 江西省科学技术协会项目(赣科协字[2018]117号);; 江西省重点研发计划项目(20181BBG78052)

作者(Author): 况弯弯;伍振峰;万娜;李远辉;王学成;康超超;刘振峰;杨明;
KUANG Wan-wan;WU Zhen-feng;WAN Na;LI Yuan-hui;WANG Xue-cheng;KANG Chao-chao;LIU Zhen-feng;YANG Ming;State Key Laboratory of Innovation Drug and Efficient Energy-saving Pharmaceutical Equipment,Jiangxi University of Traditional Chinese Medicine;Yichun Wanshen Pharmaceutical Machinery Co.,Ltd.;

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